WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556104
CAS#: 129689-28-7 (HCl)
Description: ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.
Hodoodo Cat#: H556104
Name: ZD7114 HCl
CAS#: 129689-28-7 (HCl)
Chemical Formula: C22H31ClN2O6
Exact Mass: 0.00
Molecular Weight: 454.948
Elemental Analysis: C, 58.08; H, 6.87; Cl, 7.79; N, 6.16; O, 21.10
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Related CAS #: 129689-30-1 (free base) 129689-28-7 (HCl)
Synonym: ZD 7114 hydrochloride; ZD7114 HCl; ZD7114; ZD-7114; ZD 7114; ICI-D7114; ICI-D-7114; ICI-D 7114;
IUPAC/Chemical Name: Acetamide, 2-(4-(2-((2-hydroxy-3-phenoxypropyl)amino)ethoxy)phenoxy)-N-(2-methoxyethyl)-, (S)-, hydrochloride
InChi Key: KCAMZVQSGDBGGF-FERBBOLQSA-N
InChi Code: InChI=1S/C22H30N2O6.ClH/c1-27-13-12-24-22(26)17-30-21-9-7-20(8-10-21)28-14-11-23-15-18(25)16-29-19-5-3-2-4-6-19;/h2-10,18,23,25H,11-17H2,1H3,(H,24,26);1H/t18-;/m0./s1
SMILES Code: O=C(NCCOC)COC1=CC=C(OCCNC[C@H](O)COC2=CC=CC=C2)C=C1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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| In vitro activity: | |
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The following data is based on the product molecular weight 454.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Holloway BR, Howe R, Rao BS, Stribling D. ICI D7114: a novel selective adrenoceptor agonist of brown fat and thermogenesis. Am J Clin Nutr. 1992 Jan;55(1 Suppl):262S-264S. doi: 10.1093/ajcn/55.1.262s. PMID: 1345891.
2. Holloway BR, Howe R, Rao BS, Stribling D, Mayers RM, Briscoe MG, Jackson JM. ICI D7114 a novel selective beta-adrenoceptor agonist selectively stimulates brown fat and increases whole-body oxygen consumption. Br J Pharmacol. 1991 Sep;104(1):97-104. doi: 10.1111/j.1476-5381.1991.tb12391.x. PMID: 1686210; PMCID: PMC1908265.
