WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H205856
CAS#: 1374524-55-6 (racemate)
Description: ME-344 is an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells. In pre-clinical studies, ME-344 has shown tenfold more anti-tumor activity than NV-128.
Hodoodo Cat#: H205856
Name: ME-344
CAS#: 1374524-55-6 (racemate)
Chemical Formula: C22H20O4
Exact Mass: 348.14
Molecular Weight: 348.390
Elemental Analysis: C, 75.84; H, 5.79; O, 18.37
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Related CAS #: 1374524-68-1 (RS-isomer) 1374524-55-6 (racemate)
Synonym: ME-344; ME 344; ME344.
IUPAC/Chemical Name: 4,4'-(7-hydroxy-8-methylchroman-3,4-diyl)diphenol.
InChi Key: QVCAATSEPLQVBX-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H20O4/c1-13-20(25)11-10-18-21(15-4-8-17(24)9-5-15)19(12-26-22(13)18)14-2-6-16(23)7-3-14/h2-11,19,21,23-25H,12H2,1H3
SMILES Code: CC1=C(O)C=CC2=C1OCC(C3=CC=C(O)C=C3)C2C4=CC=C(O)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: About Stereo-structure for ME-344 Drugbank listed ME344 as a single stereo-isomer(CAS#1374524-68-1, RS-isomer). In our web page, it was listed as a racemate mixture, which possibly contains 4 isomers: RR-, RR- RS-; SR-. There were at least 4 resources to support our structure: 1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959101/ This paper showed the same structure as ours. 2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432957/ This paper showed the same structure as ours. 3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697583/ This paper showed the same structure as ours. 4. Sci-Finder database (American Chemical Society) ME-344 was listed as a racemate compound.
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 348.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lim SC, Carey KT, McKenzie M. Anti-cancer analogues ME-143 and ME-344 exert
toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase
(Complex I). Am J Cancer Res. 2015 Jan 15;5(2):689-701. eCollection 2015. PubMed
PMID: 25973307; PubMed Central PMCID: PMC4396027.
