WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125232
CAS#: 109914-03-6 (2HCl)
Description: Rocastine is a rapid-acting, potent, nonsedating antihistamine. In guinea pigs challenged with a lethal dose of histamine, rocastine is as effective as brompheniramine, chlorpheniramine, pyrilamine, and promethazine and superior to astemizole, diphenhydramine, terfenadine, and oxatomide. Rocastine protected guinea pigs from collapse induced by aerosolized antigen; rocastine was approximately 36 x more potent (based on 1 hr PD50) than diphenhydramine and as potent as oxatomide and terfenadine. Rocastine did not alter the EEG of cats at doses in vast excess (150x) of its antihistaminic dose nor did it potentiate yohimbine toxicity in mice. Further, rocastine possesses no anticholinergic, antiadrenergic, or antiserotonergic properties in vitro.
Hodoodo Cat#: 125232
Name: Rocastine HCl
CAS#: 109914-03-6 (2HCl)
Chemical Formula: C13H21Cl2N3OS
Exact Mass: 337.08
Molecular Weight: 338.290
Elemental Analysis: C, 46.16; H, 6.26; Cl, 20.96; N, 12.42; O, 4.73; S, 9.48
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Related CAS #: 109914-03-6 (2HCl) 99617-35-3 (HCl hydrate) 91833-50-0 (fumarate) 91833-49-7 (free base)
Synonym: Rocastine dihydrochloride; AHR-11325; AHR 11325; AHR11325;
IUPAC/Chemical Name: 2-(2-(dimethylamino)ethyl)-4-methyl-3,4-dihydropyrido[3,2-f][1,4]oxazepine-5(2H)-thione dihydrochloride
InChi Key: YMPCDUXVFUPMJD-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H19N3OS.2ClH/c1-15(2)8-6-10-9-16(3)13(18)11-5-4-7-14-12(11)17-10;;/h4-5,7,10H,6,8-9H2,1-3H3;2*1H
SMILES Code: CN1CC(OC2=C(C1=S)C=CC=N2)CCN(C)C.Cl.Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 338.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |