WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125265
CAS#: 1571072-87-1 (besylate)
Description: KX02, also known as KX2-361, is a lipophilic, orally available inhibitor of both Src kinase activity and tubulin polymerization, with potential antineoplastic activity. Upon oral administration, src/tubulin inhibitor KX02 binds to and inhibits the activity of Src kinase. This inhibits both downstream signaling and the proliferation of Src kinase-expressing tumor cells. KX02 also binds to tubulin heterodimers and inhibits microtubule polymerization, thereby disrupting microtubule formation, mitosis, and further proliferation.
Hodoodo Cat#: 125265
Name: KX2-361 besylate
CAS#: 1571072-87-1 (besylate)
Chemical Formula: C30H30FN3O5S
Exact Mass: 563.19
Molecular Weight: 563.640
Elemental Analysis: C, 63.93; H, 5.37; F, 3.37; N, 7.46; O, 14.19; S, 5.69
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 897016-26-1 (free base) 1571072-87-1 (besylate)
Synonym: KX2-361 besylate; A718CYC1N0; UNII-A718CYC1N0; N-(3-Fluorobenzyl)-2-(5-(4-morpholinophenyl) pyridin-2-yl) acetamide besylate; 1571072-87-1
IUPAC/Chemical Name: benzenesulfonic acid;N-[(3-fluorophenyl)methyl]-2-[5-(4-morpholin-4-ylphenyl)pyridin-2-yl]acetamide
InChi Key: PTKRPOIHIOAMPP-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H24FN3O2.C6H6O3S/c25-21-3-1-2-18(14-21)16-27-24(29)15-22-7-4-20(17-26-22)19-5-8-23(9-6-19)28-10-12-30-13-11-28;7-10(8,9)6-4-2-1-3-5-6/h1-9,14,17H,10-13,15-16H2,(H,27,29);1-5H,(H,7,8,9)
SMILES Code: O=S(C1=CC=CC=C1)(O)=O.O=C(NCC2=CC=CC(F)=C2)CC3=NC=C(C4=CC=C(N5CCOCC5)C=C4)C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 563.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |