WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 333110
CAS#: 35878-41-2 (R-isomer)
Description: Vestitol is an isoflavonoid isolated from Brazilian red propolis with anti-inflammatory, antimicrobial, and anti-caries activity. Vestitol inhibited NO production by 83% at 0.55 μM without affecting cell viability when compared to the vehicle control (P < 0.05). Treatment with vestitol reduced GM-CSF, IL-6, TNF-α, IL-4 and TGF-β levels and increased IL-10 release (P < 0.05). Vestitol affected the expression of genes related to NF-κB pathway, NO synthase, and inhibition of leukocyte transmigration, namely: Ccs, Ccng1, Calm1, Tnfsf15, Il11, Gata3, Gadd45b, Cdkn1b, Csf1, Ccl5, Birc3 (negatively regulated), and Igf1 (positively regulated). Vestitol diminished the activation of NF-κB and Erk 1/2 pathways and induced macrophages into M2-like polarization. Vestitol is the R-isomer. (+)-Vestitol, also known as (3S)-Vestitol, is an S-isomer of Vestitol.
Hodoodo Cat#: 333110
Name: Vestitol
CAS#: 35878-41-2 (R-isomer)
Chemical Formula: C16H16O4
Exact Mass: 272.10
Molecular Weight: 272.300
Elemental Analysis: C, 70.58; H, 5.92; O, 23.50
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Related CAS #: 20879-05-4 (S-isomer) 35878-41-2 (R-isomer)
Synonym: Vestitol; (3R)-Vestitol; (-)-Vestitol;
IUPAC/Chemical Name: (3R)-3-(2-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
InChi Key: XRVFNNUXNVWYTI-NSHDSACASA-N
InChi Code: InChI=1S/C16H16O4/c1-19-13-4-5-14(15(18)8-13)11-6-10-2-3-12(17)7-16(10)20-9-11/h2-5,7-8,11,17-18H,6,9H2,1H3/t11-/m0/s1
SMILES Code: OC1=CC2=C(C=C1)C[C@H](C3=CC=C(OC)C=C3O)CO2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 272.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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