RO-5508887 HCl

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Hodoodo CAT#: 125452

CAS#: 1310349-35-9 (HCl)

Description: RO5508887, also known as RG-7129, is a potent BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM).

Chemical Structure

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RO-5508887 HCl
CAS# 1310349-35-9 (HCl)
Instruction

Theoretical Analysis

Hodoodo Cat#: 125452
Name: RO-5508887 HCl
CAS#: 1310349-35-9 (HCl)
Chemical Formula: C18H15ClF3N5O2
Exact Mass: 425.09
Molecular Weight: 425.800
Elemental Analysis: C, 50.77; H, 3.55; Cl, 8.33; F, 13.39; N, 16.45; O, 7.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1310347-50-2 (free base)   1310349-35-9 (HCl)  

Synonym: 8PU77BD4DA; RO-5508887 hydrochloride; UNII-8PU77BD4DA; 310349-35-9

IUPAC/Chemical Name: (R)-N-(3-(2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide hydrochloride

InChi Key: CNXVOHMMAKBONG-UNTBIKODSA-N

InChi Code: InChI=1S/C18H14F3N5O2.ClH/c1-17(18(20,21)9-28-16(23)26-17)12-6-11(3-4-13(12)19)25-15(27)14-5-2-10(7-22)8-24-14;/h2-6,8H,9H2,1H3,(H2,23,26)(H,25,27);1H/t17-;/m1./s1

SMILES Code: Cl.C[C@@]1(N=C(N)OCC1(F)F)C2=CC(NC(=O)C3=NC=C(C=C3)C#N)=CC=C2F

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D,
Tanghe A, Bohrmann B. Combined treatment with a BACE inhibitor and anti-Aβ
antibody gantenerumab enhances amyloid reduction in APPLondon mice. J Neurosci.
2014 Aug 27;34(35):11621-30. doi: 10.1523/JNEUROSCI.1405-14.2014. PubMed PMID:
25164658; PubMed Central PMCID: PMC4145168.

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