WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125464
CAS#: 1356154-94-3 (HCl)
Description: VS-4718 is an oral small molecule inhibitor of FAK and PYK2.
Hodoodo Cat#: 125464
Name: VS-4718 HCl
CAS#: 1356154-94-3 (HCl)
Chemical Formula: C25H27ClF3N5O3
Exact Mass: 537.18
Molecular Weight: 537.970
Elemental Analysis: C, 55.82; H, 5.06; Cl, 6.59; F, 10.59; N, 13.02; O, 8.92
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1061353-68-1 (free base) 1356154-94-3 (HCl)
Synonym: PND-1186 hydrochloride; 1356154-94-3; PND-1186 (Hydrochloride); SR-2516 hydrochloride; VS-4718 hydrochloride
IUPAC/Chemical Name: 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide hydrochloride
InChi Key: OWQFAUOQRRIFLB-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H26F3N5O3.ClH/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33;/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32);1H
SMILES Code: Cl.CNC(=O)C1=C(NC2=C(C=NC(NC3=CC=C(C=C3OC)N4CCOCC4)=C2)C(F)(F)F)C=CC=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 537.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD. FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Mol Cancer Ther. 2014 Aug;13(8):2050-61. doi: 10.1158/1535-7163.MCT-13-1063. Epub 2014 Jun 4. PubMed PMID: 24899686; PubMed Central PMCID: PMC4126870.