WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125566
CAS#: 1454806-18-8 (HCl)
Description: Vesatolimod, also known as GS-9620, is a potent and oral agonist of Toll-like receptor-7 developed for finite treatment of chronic hepatitis B viral (HBV) infection, with the goal of inducing a liver-targeted antiviral effect without inducing the adverse effects associated with current systemic interferon-α (IFN-α) therapies. GS-9620 demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. GS-9620 can induce a sustained antiviral response in the woodchuck model of CHB.
Hodoodo Cat#: 125566
Name: Vesatolimod HCl
CAS#: 1454806-18-8 (HCl)
Chemical Formula: C22H31ClN6O2
Exact Mass: 446.22
Molecular Weight: 446.980
Elemental Analysis: C, 59.12; H, 6.99; Cl, 7.93; N, 18.80; O, 7.16
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Related CAS #: 1228585-88-3 (free base) 1454806-18-8 (HCl)
Synonym: Vesatolimod hydrochloride; UNII-4PXC90RF2J; 4PXC90RF2J 6(5H)-Pteridinone, 4-amino-2-butoxy-7,8-dihydro-8-((3-(1-pyrrolidinylmethyl)phenyl)methyl)-, hydrochloride (1:1); 1454806-18-8
IUPAC/Chemical Name: 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one hydrochloride
InChi Key: SOSJWFFUCUGLER-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30N6O2.ClH/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27;/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26);1H
SMILES Code: Cl.CCCCOC1=NC2=C(NC(=O)CN2CC3=CC(CN4CCCC4)=CC=C3)C(N)=N1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 446.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
