WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125598
CAS#: Amg-900 bismesylate dihydrate
Description: AMG 900 is a small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.
Hodoodo Cat#: 125598
Name: Amg-900 bismesylate dihydrate
CAS#: Amg-900 bismesylate dihydrate
Chemical Formula: C30H33N7O9S3
Exact Mass: 731.15
Molecular Weight: 731.810
Elemental Analysis: C, 49.24; H, 4.55; N, 13.40; O, 19.68; S, 13.14
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Related CAS #: Amg-900 bismesylate dihydrate 945595-80-2 (free base)
Synonym: E717YSV70L; AMG-900 BISMESYLATE DIHYDRATE; N-(4-(3-(2-AMINOPYRIMIDIN-4-YL)PYRIDIN-2-YL)OXY)PHENYL)-4-(4-METHYLTHIOPHEN-2-YL)PHTHALAZIN-1-AMINE BIS-MESYLATE DIHYDRATE
IUPAC/Chemical Name: N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine dimethanesulfonate dihydrate
InChi Key: LINJGTOZMRMDBO-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H21N7OS.2CH4O3S.2H2O/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23;2*1-5(2,3)4;;/h2-16H,1H3,(H,32,35)(H2,29,31,33);2*1H3,(H,2,3,4);2*1H2
SMILES Code: O.O.CS(O)(=O)=O.CS(O)(=O)=O.CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=NC=CC=C4C5=NC(N)=NC=C5)C=C3)C6=C2C=CC=C6
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 731.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |