WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125706
CAS#: 1422006-47-0 (monophosphate)
Description: Sapanisertib, also known as TAK-228, MLN0128 and INK128, is a TORC1/2 inhibitor, is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.
Hodoodo Cat#: 125706
Name: Sapanisertib monophosphate
CAS#: 1422006-47-0 (monophosphate)
Chemical Formula: C15H18N7O5P
Exact Mass: 407.11
Molecular Weight: 407.330
Elemental Analysis: C, 44.23; H, 4.45; N, 24.07; O, 19.64; P, 7.60
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Related CAS #: 1422006-47-0 (monophosphate) 1224844-38-5 (free base) 1422006-46-9 (HCl) 1422006-35-6 (2HCl)
Synonym: Sapanisertib monophosphate; UNII-3N20L7V8XK; 3N20L7V8XK; 1422006-47-0; 1H-Pyrazolo(3,4-d)pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-, phosphate (1:1)
IUPAC/Chemical Name: 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine phosphate
InChi Key: ZCBRZSQEWLAEHT-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H15N7O.H3O4P/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10;1-5(2,3)4/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19);(H3,1,2,3,4)
SMILES Code: OP(O)(O)=O.CC(C)N1N=C(C2=C(N)N=CN=C12)C3=CC=C4OC(N)=NC4=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 407.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Maiso P, Liu Y, Morgan B, Azab A, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A, Ngo H, Azab F, Quang P, Rodig SJ, Lin CP, Roccaro A, Rommel C, Ghobrial IM. Defining the role of TORC1 and TORC2 in multiple myeloma. Blood. 2011 Nov 1. [Epub ahead of print] PubMed PMID: 22045983.