WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H205745
CAS#: 1246203-36-0 (mesylate)
Description: PWT33597, also known as VDC-597, is an orally bioavailable dual inhibitor of phosphatidylinositide 3-kinase (PI3K) alpha and mammalian target of rapamycin (mTOR) kinase with potential antineoplastic activity. PI3K alpha/mTOR dual inhibitor PWT33597 selectively inhibits both PI3K alpha kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells.
Hodoodo Cat#: H205745
Name: PWT33597 mesylate
CAS#: 1246203-36-0 (mesylate)
Chemical Formula: C27H34F2N8O7S2
Exact Mass: 0.00
Molecular Weight: 684.735
Elemental Analysis: C, 47.36; H, 5.01; F, 5.55; N, 16.36; O, 16.36; S, 9.36
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Related CAS #: 1246203-32-6 (free base) 1246203-36-0 (mesylate)
Synonym: PWT33597 ; PWT 33597; PWT33597; VDC-597; VDC597; VDC 597; PWT33597 mesylate
IUPAC/Chemical Name: N-(4-(4-(2-(difluoromethyl)-4-methoxy-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-2-(dimethylamino)ethane-1-sulfonamide mesylate
InChi Key: XSLUGEGXPCDRTN-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H30F2N8O4S.CH4O3S/c1-34(2)13-16-41(37,38)33-18-9-7-17(8-10-18)23-30-25(35-11-14-40-15-12-35)32-26(31-23)36-19-5-4-6-20(39-3)21(19)29-24(36)22(27)28;1-5(2,3)4/h4-10,22,33H,11-16H2,1-3H3;1H3,(H,2,3,4)
SMILES Code: O=S(CCN(C)C)(NC1=CC=C(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)C=C1)=O.OS(=O)(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: PWT33597 is currently being developed by Pathyway Theraceuptics, which demonstrates excellent in vitro selectivity for its targets, with negligible activity against other lipid kinases, protein kinases and other pharmacologically relevant targets at biologically active concentrations. The compound achieves good distribution into tumors, robust pathway inhibition and excellent oral efficacy in multiple xenograft across varying genetic backgrounds. PWT33597 has an excellent DMPK and safety profile and is an attractive candidate for use as single agent and combination therapy. (source: http://pathwaytx.com/product_pipeline.html). Chemical structure was from https://figshare.com/articles/Chemical_structure_of_VDC-597_/6822143/1
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The following data is based on the product molecular weight 684.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |