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Tymazoline HCl
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H318963

CAS#: 28120-03-8 (hydrochloride)

Description: Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis. It acts as an antihistaminic and sympathomimetic, reducing swelling, inflammation and mucosal secretions.

Chemical Structure

Tymazoline HCl

CAS# 28120-03-8 (hydrochloride)

Instruction

Theoretical Analysis

Hodoodo Cat#: H318963
Name: Tymazoline HCl
CAS#: 28120-03-8 (hydrochloride)
Chemical Formula: C14H21ClN2O
Exact Mass: 0.00
Molecular Weight: 268.785
Elemental Analysis: C, 62.56; H, 7.88; Cl, 13.19; N, 10.42; O, 5.95

Price and Availability

Size	Price	Availability	Quantity
200mg	USD 450
500mg	USD 650
1g	USD 950
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: D08658; Tymazoline HCl, trade name: Thymazen; Pernazene.

IUPAC/Chemical Name: 2-[(5-methyl-2-propan-2-ylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride

InChi Key:

InChi Code:

SMILES Code: CC(C1=CC=C(C)C=C1OCC2=NCCN2)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 268.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Antoniou CG, Markopoulou CK, Kouskoura MG, Koundourellis JE. Study and
development of reversed-phase HPLC systems for the determination of
2-imidazolines in the presence of preservatives in pharmaceutical preparations. J
AOAC Int. 2011 May-Jun;94(3):703-12. PubMed PMID: 21796997.

2: Levrier J, Molon-Noblot S, Duval D, Lloyd KG. A new ex vivo method for the
study of nasal drops on ciliary function. Fundam Clin Pharmacol.
1989;3(5):471-82. PubMed PMID: 2481638.