WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H317170
CAS#: 181183-52-8(Almotriptan Malate)
Description: Almotriptan Malate is a triptan drug discovered and developed by Almirall for the treatment of heavy migraine headache. Almotriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist. Binding of the drug to the receptor leads to vasoconstriction of the cranial blood vessels and thus affects the redistribution of cranial blood flow. Almotriptan significantly increases cerebral blood flow and reduces blood flow through extracerebral cranial vessels. Even though it affects cranial blood vessels a single dose of almotriptan (12.5 mg) has no clinically significant effect on blood pressure or heart rate in both young and elderly healthy volunteers.
Hodoodo Cat#: H317170
Name: Almotriptan Malate
CAS#: 181183-52-8(Almotriptan Malate)
Chemical Formula: C17H25N3O2S
Exact Mass: 335.17
Molecular Weight: 335.460
Elemental Analysis: C, 60.87; H, 7.51; N, 12.53; O, 9.54; S, 9.56
Related CAS #: 181183-52-8(Almotriptan Malate) 154323-57-6 (free base)
Synonym: Almogran; Almotrex; Amignul; Axert; Almotriptan Malate.
IUPAC/Chemical Name: N,N-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-3-yl)ethan-1-amine 2-hydroxysuccinate
InChi Key: QHATUKWEVNMHRY-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
SMILES Code: CN(CCC1=CNC2=C1C=C(CS(=O)(N3CCCC3)=O)C=C2)C.O=C(O)C(O)CC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related: 181183-52-8 (Almotriptan free base) 154323-57-6 (Almotriptan HCl)
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 335.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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