Ritobegron HCl

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Hodoodo CAT#: H319598

CAS#: 476333-91-2 (HCl)

Description: Ritobegron, also known as KUC-7483, is a potent and selective β3-adrenoceptor agonist. Ritobegron displayed potent and selective β(3)-AR agonistic activity toward transfected human β-AR and exhibited a high selectivity for the bladder versus other organs in rats. Ritobegron decreased intravesical pressure with minimal effects on the cardiovascular system in anesthetized rats. Ritobegron shows promise as a potential agent for the treatment of overactive bladder.

Chemical Structure

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Ritobegron HCl
CAS# 476333-91-2 (HCl)
Instruction

Theoretical Analysis

Hodoodo Cat#: H319598
Name: Ritobegron HCl
CAS#: 476333-91-2 (HCl)
Chemical Formula: C23H32ClNO5
Exact Mass: 0.00
Molecular Weight: 437.961
Elemental Analysis: C, 63.08; H, 7.37; Cl, 8.09; N, 3.20; O, 18.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
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Related CAS #: 476333-91-2 (HCl)   255733-81-4 (free base)    

Synonym: KUC-7483; KUC 7483; KUC7483; Ritobegron; Ritobegron HCl; Ritobegron hydrochloride; brand name: Myrbetriq.

IUPAC/Chemical Name: ethyl 2-(4-(2-(((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)amino)ethyl)-2,5-dimethylphenoxy)acetate hydrochloride

InChi Key: SDZAMDXEQUMDBE-DQFHVVJASA-N

InChi Code: InChI=1S/C23H31NO5.ClH/c1-5-28-22(26)14-29-21-13-15(2)19(12-16(21)3)10-11-24-17(4)23(27)18-6-8-20(25)9-7-18;/h6-9,12-13,17,23-25,27H,5,10-11,14H2,1-4H3;1H/t17-,23-;/m0./s1

SMILES Code: O=C(OCC)COC1=CC(C)=C(CCN[C@@H](C)[C@H](O)C2=CC=C(O)C=C2)C=C1C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 437.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abe Y, Ota E, Endo T, Murakami M, Kobayashi M. Absorption, disposition,
metabolism, and excretion of ritobegron (KUC-7483), a novel selective
β3-adrenoceptor agonist, in rats. Pharmazie. 2014 Dec;69(12):881-8. PubMed PMID:
25951660.


2: Maruyama I, Goi Y, Tatemichi S, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H.
Bladder selectivity of the novel β₃-agonist ritobegron (KUC-7483) explored by in
vitro and in vivo studies in the rat. Naunyn Schmiedebergs Arch Pharmacol. 2012
Aug;385(8):845-52. doi: 10.1007/s00210-012-0755-x. Epub 2012 May 3. PubMed PMID:
22552730.


3: Maruyama I, Tatemichi S, Goi Y, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H.
Effects of ritobegron (KUC-7483), a novel selective β3-adrenoceptor agonist, on
bladder function in cynomolgus monkey. J Pharmacol Exp Ther. 2012
Jul;342(1):163-8. doi: 10.1124/jpet.112.191783. Epub 2012 Apr 16. PubMed PMID:
22511202.


4: Maruyama I, Yonekubo S, Tatemichi S, Maruyama K, Hoyano Y, Yamazaki Y, Kusama
H. Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat
bladder function following partial bladder outlet obstruction and on rat salivary
secretion: a comparison with the effects of tolterodine. J Smooth Muscle Res.
2012;48(5-6):115-24. PubMed PMID: 23538508.