RO5263397 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H522568

CAS#: 1357266-05-7 (free base)

Description: RO5263397 is a selective TAAR 1 agonist. RO5263397 was efficacious in reducing cocaine-mediated behaviors. RO5263397 dose-dependently prevented cocaine-induced lowering of ICSS thresholds. TAAR1 stimulation effectively suppresses the rewarding and reinforcing effects of cocaine in self-administration and ICSS models, supporting the candidacy of TAAR1 as a drug discovery target for cocaine addiction.

Chemical Structure

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RO5263397 HCl
CAS# 1357266-05-7 (free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H522568
Name: RO5263397 HCl
CAS#: 1357266-05-7 (free base)
Chemical Formula: C10H13Cl2FN2O
Exact Mass: 0.00
Molecular Weight: 267.125
Elemental Analysis: C, 44.96; H, 4.91; Cl, 26.54; F, 7.11; N, 10.49; O, 5.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1357266-05-7 (free base)   CAS# unknown for HCl,  

Synonym: RO5263397; RO-5263397; RO 5263397.

IUPAC/Chemical Name: (S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine dihydrochloride

InChi Key: GZJSFLYZAYEEKB-KLQYNRQASA-N

InChi Code: InChI=1S/C10H11FN2O.2ClH/c1-6-7(3-2-4-8(6)11)9-5-14-10(12)13-9;;/h2-4,9H,5H2,1H3,(H2,12,13);2*1H/t9-;;/m1../s1

SMILES Code: NC1=N[C@@H](C2=C(C)C(F)=CC=C2)CO1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 267.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace
amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents
cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol
Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015
Jun 3. PubMed PMID: 26048337.


2: Jing L, Zhang Y, Li JX. Effects of the trace amine associated receptor 1
agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats.
Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu060. doi:
10.1093/ijnp/pyu060. PubMed PMID: 25522401; PubMed Central PMCID: PMC4360231.


3: Fowler S, Kletzl H, Finel M, Manevski N, Schmid P, Tuerck D, Norcross RD,
Hoener MC, Spleiss O, Iglesias VA. A UGT2B10 splicing polymorphism common in
african populations may greatly increase drug exposure. J Pharmacol Exp Ther.
2015 Feb;352(2):358-67. doi: 10.1124/jpet.114.220194. Epub 2014 Dec 12. PubMed
PMID: 25503386.


4: Thorn DA, Jing L, Qiu Y, Gancarz-Kausch AM, Galuska CM, Dietz DM, Zhang Y, Li
JX. Effects of the trace amine-associated receptor 1 agonist RO5263397 on
abuse-related effects of cocaine in rats. Neuropsychopharmacology. 2014
Sep;39(10):2309-16. doi: 10.1038/npp.2014.91. Epub 2014 Apr 18. PubMed PMID:
24743376; PubMed Central PMCID: PMC4138753.


5: Thorn DA, Zhang C, Zhang Y, Li JX. The trace amine associated receptor 1
agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in
rats. Neurosci Lett. 2014 Apr 30;566:67-71. doi: 10.1016/j.neulet.2014.02.024.
Epub 2014 Feb 21. PubMed PMID: 24561093; PubMed Central PMCID: PMC3991844.


6: Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz
S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR,
Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. A new perspective
for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like
activity, improve cognition and control body weight. Mol Psychiatry. 2013
May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29. PubMed PMID:
22641180.