WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206521
CAS#: 1449768-48-2 (HCl)
Description: SLP7111228 is a selective inhibitor of sphingosine kinase type 1 (SphK1). It consists of a pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.
Hodoodo Cat#: H206521
Name: SLP7111228 HCl
CAS#: 1449768-48-2 (HCl)
Chemical Formula: C22H34ClN5O
Exact Mass: 0.00
Molecular Weight: 420.000
Elemental Analysis: C, 62.92; H, 8.16; Cl, 8.44; N, 16.68; O, 3.81
Related CAS #: 1449765-82-5 (free base) 1449768-48-2 (HCl)
Synonym: SLP7111228; SLP-7111228; SLP 7111228.
IUPAC/Chemical Name: (S)-2-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)pyrrolidine-1-carboximidamide hydrochloride
InChi Key: REAGUXWEQBFUPB-FYZYNONXSA-N
InChi Code: InChI=1S/C22H33N5O.ClH/c1-2-3-4-5-6-7-9-17-11-13-18(14-12-17)21-25-20(28-26-21)16-19-10-8-15-27(19)22(23)24;/h11-14,19H,2-10,15-16H2,1H3,(H3,23,24);1H/t19-;/m0./s1
SMILES Code: N=C(N1[C@H](CC2=NC(C3=CC=C(CCCCCCCC)C=C3)=NO2)CCC1)N.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 420.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR,
Santos WL. Structure-activity relationship studies and in vivo activity of
guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and
SphK2-selective inhibitors. J Med Chem. 2015 Feb 26;58(4):1879-99. doi:
10.1021/jm501760d. Epub 2015 Feb 13. PubMed PMID: 25643074; PubMed Central PMCID:
PMC4557804.
