WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319657
CAS#: 351227-64-0 (free base)
Description: Fosravuconazole, also known as BEF-1224; BMS-379224; E-1224, is an azole antifungal agent potentially for the treatment of fungal infections.
Hodoodo Cat#: H319657
Name: Fosravuconazole
CAS#: 351227-64-0 (free base)
Chemical Formula: C23H20F2N5O5PS
Exact Mass: 547.09
Molecular Weight: 547.474
Elemental Analysis: C, 50.46; H, 3.68; F, 6.94; N, 12.79; O, 14.61; P, 5.66; S, 5.86
Related CAS #: 351227-64-0 (free base) 914361-44-7 (monolysine) 914361-45-8 (L-lysine ethanolate)
Synonym: Fosravuconazole; BEF-1224; BMS-379224; E-1224; BEF1224; BMS379224; E1224.
IUPAC/Chemical Name: (((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl dihydrogen phosphate
InChi Key: SYTNEMZCCLUTNX-NPMXOYFQSA-N
InChi Code: InChI=1S/C23H20F2N5O5PS/c1-15(22-29-21(10-37-22)17-4-2-16(9-26)3-5-17)23(11-30-13-27-12-28-30,34-14-35-36(31,32)33)19-7-6-18(24)8-20(19)25/h2-8,10,12-13,15H,11,14H2,1H3,(H2,31,32,33)/t15-,23+/m0/s1
SMILES Code: N#CC1=CC=C(C2=CSC([C@H](C)[C@@](OCOP(O)(O)=O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)=N2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS#. 351227-64-0 (Fosravuconazole) 351228-71-2 (Fosravuconazole bis(L-lysine))
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The following data is based on the product molecular weight 547.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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