WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319775
CAS#: 204386-76-5 (free base)
Description: Rovatirelin, also known as S-0373, is a novel synthetic agent that mimics the actions of thyrotropin-releasing hormone (TRH). Rovatirelin binds to the human TRH receptor with higher affinity (Ki=702nM) than taltirelin (Ki=3877nM). Rovatirelin increased the spontaneous firing of action potentials in the acutely isolated noradrenergic neurons of rat locus coeruleus (LC). Rovatirelin increased locomotor activity. Rovatirelin may have an orally effective therapeutic potential in patients with SCD.
Hodoodo Cat#: H319775
Name: Rovatirelin
CAS#: 204386-76-5 (free base)
Chemical Formula: C17H24N4O4S
Exact Mass: 380.15
Molecular Weight: 380.463
Elemental Analysis: C, 53.67; H, 6.36; N, 14.73; O, 16.82; S, 8.43
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Related CAS #: 204386-76-5 (free base) 879122-87-9 (hydrate)
Synonym: Rovatirelin; S-0373; S 0373; S0373.
IUPAC/Chemical Name: (4S,5S)-5-methyl-N-((S)-1-((R)-2-methylpyrrolidin-1-yl)-1-oxo-4-(thiazol-4-yl)butan-2-yl)-2-oxooxazolidine-4-carboxamide
InChi Key: INIHZNPGJLNXFJ-XWUBHJNHSA-N
InChi Code: InChI=1S/C17H24N4O4S/c1-10-4-3-7-21(10)16(23)13(6-5-12-8-26-9-18-12)19-15(22)14-11(2)25-17(24)20-14/h8-11,13-14H,3-7H2,1-2H3,(H,19,22)(H,20,24)/t10-,11+,13+,14+/m1/s1
SMILES Code: O=C([C@H]1NC(O[C@H]1C)=O)N[C@@H](CCC2=CSC=N2)C(N3[C@H](C)CCC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 204386-76-5 (Rovatirelin) 879122-87-9 (Rovatirelin Hydrate)
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 380.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ijiro T, Nakamura K, Ogata M, Inada H, Kiguchi S, Maruyama K, Nabekura J,
Kobayashi M, Ishibashi H. Effect of rovatirelin, a novel thyrotropin-releasing
hormone analog, on the central noradrenergic system. Eur J Pharmacol. 2015 Aug
15;761:413-22. doi: 10.1016/j.ejphar.2015.05.047. Epub 2015 Jul 2. PubMed PMID:
26142830.