WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319787
CAS#: 869880-33-1 (HCl salt)
Description: Fasitibant chloride, also known as MEN16132, is a potent and selective nonpeptide kinin B2 receptor antagonist. MEN16132 inhibited in a dose-dependent manner the bronchoconstriction induced by BK (10 nmol/kg i.v.). MEN16132 was more potent and possessed a longer duration of action as compared with the peptide B(2) receptor antagonist icatibant.
Hodoodo Cat#: H319787
Name: Fasitibant chloride (HCl salt)
CAS#: 869880-33-1 (HCl salt)
Chemical Formula: C36H50Cl4N6O6S
Exact Mass: 0.00
Molecular Weight: 836.692
Elemental Analysis: C, 51.68; H, 6.02; Cl, 16.95; N, 10.04; O, 11.47; S, 3.83
Related CAS #: 869880-33-1 (HCl salt) 1157852-02-2 (Chloride)
Synonym: MEN16132; MEN-16132; MEN 16132; Fasitibant chloride
IUPAC/Chemical Name: (S)-4-amino-5-(4-(4-((2,4-dichloro-3-(((2,4-dimethylquinolin-8-yl)oxy)methyl)phenyl)sulfonamido)tetrahydro-2H-pyran-4-carbonyl)piperazin-1-yl)-N,N,N-trimethyl-5-oxopentan-1-aminium chloride hydrochloride
InChi Key: QIAWOUUTKDMGTE-UJXPALLWSA-M
InChi Code: InChI=1S/C36H49Cl2N6O6S.2ClH/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)50-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-49-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5;;/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3;2*1H/q+1;;/p-1/t29-;;/m0../s1
SMILES Code: O=C(N1CCN(C(C2(NS(=O)(C3=CC=C(Cl)C(COC4=C5N=C(C)C=C(C)C5=CC=C4)=C3Cl)=O)CCOCC2)=O)CC1)[C@@H](N)CCC[N+](C)(C)C.[H]Cl.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 836.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
