WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522632
CAS#: 276702-15-9
Description: SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner.
Hodoodo Cat#: H522632
Name: SB-332235
CAS#: 276702-15-9
Chemical Formula: C13H10Cl3N3O4S
Exact Mass: 408.95
Molecular Weight: 410.650
Elemental Analysis: C, 38.02; H, 2.45; Cl, 25.90; N, 10.23; O, 15.58; S, 7.81
Synonym: SB-332235; SB 332235; SB332235.
IUPAC/Chemical Name: 6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide
InChi Key:
InChi Code:
SMILES Code: ClC1=CC=CC(NC(NC2=C(O)C(S(=O)(N)=O)=C(Cl)C=C2)=O)=C1Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 410.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wang Y, Luo W, Stricker R, Reiser G. Protease-activated receptor-1 protects
rat astrocytes from apoptotic cell death via JNK-mediated release of the
chemokine GRO/CINC-1. J Neurochem. 2006 Aug;98(4):1046-60. Epub 2006 Jun 2.
PubMed PMID: 16749907.
2: Stevenson CS, Coote K, Webster R, Johnston H, Atherton HC, Nicholls A,
Giddings J, Sugar R, Jackson A, Press NJ, Brown Z, Butler K, Danahay H.
Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory
changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am J
Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29. PubMed
PMID: 15516486.