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Guanethidine Sulfate
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Hodoodo CAT#: H317983

CAS#: 645-43-2 (sulfate)

Description: Guanethidine sulfate is an antihypertensive agent that inhibits selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

Chemical Structure

Guanethidine Sulfate

CAS# 645-43-2 (sulfate)

Instruction

Theoretical Analysis

Hodoodo Cat#: H317983
Name: Guanethidine Sulfate
CAS#: 645-43-2 (sulfate)
Chemical Formula: C10H24N4O4S
Exact Mass: 0.00
Molecular Weight: 296.386
Elemental Analysis: C, 40.52; H, 8.16; N, 18.90; O, 21.59; S, 10.82

Price and Availability

Size	Price	Availability
100mg	USD 285	2 Weeks
500mg	USD 550	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 55-65-2 (free) 645-43-2 (sulfate) 60-02-6 (hemisulfate)

Synonym: Guanethidine Sulfate; Guanethidine monosulfate; Ismelin sulfate; Guanethidine (sulfate); UNII-5UBY8Y002G; Octadine; Oktadin; Sulfate, Guanethidine;

IUPAC/Chemical Name: 2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric acid

InChi Key: YUFWAVFNITUSHI-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)

SMILES Code: C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 296.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Herskovits MS, Singh IJ. Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats. J Exp Zool. 1982 Sep 20;223(1):97-101. PubMed PMID: 7130940.

2: Ourgaud AG, Chagnon A. [Guanethidine sulfate (ismeline) and adrenaline in the treatment of postoperative secondary and residual glaucoma]. Bull Soc Ophtalmol Fr. 1976 May-Jun;76(5-6):517-21. French. PubMed PMID: 1052150.

3: Lenzi F, Gerola A. [The effects of electric stimulation of the hypothalamus on pulmonary circulation in the cat. II. Blocking action of guanethidine sulfate]. Boll Soc Ital Biol Sper. 1969 Aug 31;45(16):1091-5. Italian. PubMed PMID: 5374946.

4: Mitchell JR, Arias L, Oates JA. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973-6. PubMed PMID: 5630743.

5: CHANDRASEKAR RG, COPPO JO, DUANE GW, PIERRE G, THURMANN M, UTLEY JH, JANNEY JG Jr. Clinical evaluation of guanethidine sulfate, a new antihypertensive agent. Am Heart J. 1962 Mar;63:309-19. PubMed PMID: 13878057.

6: GILLIS CN, NASH CW. The initial pressor actions of bretylium tosylate and guanethidine sulfate and their relation to release of catecholamines. J Pharmacol Exp Ther. 1961 Oct;134:1-7. PubMed PMID: 13898659.

7: LECKERT JT. The antihypertensive effect of guanethidine sulfate. Discussion. J La State Med Soc. 1961 Aug;113:345-6. PubMed PMID: 13760083.

8: ZIEGLER RW, SIGNORELLI JJ, DUPUY HJ. The antihypertensive effect of guanethidine sulfate. J La State Med Soc. 1961 Jun;113:221-3. PubMed PMID: 13788429.

9: Haddad HM. Management of surgical overcorrection of ptosis with topical guanethidine sulfate: a case report. Metab Pediatr Syst Ophthalmol. 1982;6(3-4):285-6. PubMed PMID: 7185020.

10: Brown BT, Carrion HM, Politano VA. Guanethidine sulfate in the prevention of autonomic hyperreflexia. J Urol. 1979 Jul;122(1):55-7. PubMed PMID: 458989.

11: Beetz D. [Decline of spermiogram modifications after termination of guanethidine sulfate application]. Andrologie. 1972;4(3):239-44. German. PubMed PMID: 4676474.

12: Storch J. [Action of 5 per cent guanethidine sulfate (ismeline) eye drops on lid retraction during Basedow's disease]. Ann Ocul (Paris). 1971 Jun;204(6):627-44. French. PubMed PMID: 5109312.

13: Pianciola AC. [Guanethidine sulfate collyrium]. Arch Oftalmol B Aires. 1971 May-Jun;46(5):46-7. Spanish. PubMed PMID: 5128656.

14: Tománková H. [Determination of (2-(octahydro-1'-azocinyl)ethyl) guanidine sulfate (guanethidine sulfate) in non-aqueous mdium. Thin layer chromatography of guanethidine sulfate]. Cesk Farm. 1970 Apr;19(3):96-8. Czech. PubMed PMID: 5423295.

15: Bonomi L, DiComite P. Outflow facility after guanethidine sulfate administration. Arch Ophthalmol. 1967 Sep;78(3):337-40. PubMed PMID: 6040011.

16: SHAPIRO AP, KRIFCHER E. PRESSOR RESPONSES TO NOXIOUS STIMULI IN HYPERTENSIVE PATIENTS: EFFECTS OF GUANETHIDINE SULFATE AND ALPHA METHYLDOPA. Circulation. 1964 Nov;30:671-8. PubMed PMID: 14230935.

17: GREENSTEIN S. Severe essential hypertension treated by guanethidine sulfate with hydrochlorthiazide. J Albert Einstein Med Cent (Phila). 1961 Jul;9:198-205. PubMed PMID: 13708357.