Ketoprofen
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H318080

CAS#: 22071-15-4 (free base)

Description: Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin.

Chemical Structure

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Ketoprofen
CAS# 22071-15-4 (free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H318080
Name: Ketoprofen
CAS#: 22071-15-4 (free base)
Chemical Formula: C16H14O3
Exact Mass: 254.09
Molecular Weight: 254.281
Elemental Analysis: C, 75.57; H, 5.55; O, 18.88

Price and Availability

Size Price Availability Quantity
1g USD 150 Ready to ship
2g USD 250 Ready to ship
5g USD 450 2 Weeks
10g USD 700 2 Weeks
25g USD 1250 2 Weeks
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Related CAS #: 22071-15-4 (free base)   57469-78-0 ( lysinate)   76690-94-3 (glucuronide)   57495-14-4 (sodium)  

Synonym: Ketoprofen, Profenid, Orudis, Alrheumun, Capisten

IUPAC/Chemical Name: 2-(3-benzoylphenyl)propanoic acid

InChi Key: DKYWVDODHFEZIM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

SMILES Code: CC(C1=CC=CC(C(C2=CC=CC=C2)=O)=C1)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 254.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Damulin IV. [Treatment of back pain (ketoprofen and other methods)]. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(2):81-6. Review. Russian. PubMed PMID: 24730046.

2: Sarzi-Puttini P, Atzeni F, Lanata L, Bagnasco M. Efficacy of ketoprofen vs. ibuprofen and diclofenac: a systematic review of the literature and meta-analysis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):731-8. Epub 2013 May 17. Review. PubMed PMID: 23711416.

3: Shohin IE, Kulinich JI, Ramenskaya GV, Abrahamsson B, Kopp S, Langguth P, Polli JE, Shah VP, Groot DW, Barends DM, Dressman JB. Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen. J Pharm Sci. 2012 Oct;101(10):3593-603. doi: 10.1002/jps.23233. Epub 2012 Jul 11. Review. PubMed PMID: 22786667.

4: Gigante A, Tagarro I. Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole. Clin Drug Investig. 2012 Apr 1;32(4):221-33. doi: 10.2165/11596670-000000000-00000. Review. PubMed PMID: 22350497.

5: Coaccioli S. Ketoprofen 2.5% gel: a clinical overview. Eur Rev Med Pharmacol Sci. 2011 Aug;15(8):943-9. Review. PubMed PMID: 21845805.

6: Adachi H, Ioppolo F, Paoloni M, Santilli V. Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch: a new patch formulation. Eur Rev Med Pharmacol Sci. 2011 Jul;15(7):823-30. Review. PubMed PMID: 21780552.

7: Kokki H. Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients. Paediatr Drugs. 2010 Oct 1;12(5):313-29. doi: 10.2165/11534910-000000000-00000. Review. PubMed PMID: 20799760.

8: Sarzi-Puttini P, Atzeni F, Lanata L, Bagnasco M, Colombo M, Fischer F, D'Imporzano M. Pain and ketoprofen: what is its role in clinical practice? Reumatismo. 2010 Jul-Sep;62(3):172-88. Review. PubMed PMID: 21052564.

9: Cantisani C, Grieco T, Faina V, Mattozzi C, Bohnenberger H, Silvestri E, Calvieri S. Ketoprofen allergic reactions. Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):58-64. Review. PubMed PMID: 19832694.

10: Barden J, Derry S, McQuay HJ, Moore RA. Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007355. doi: 10.1002/14651858.CD007355.pub2. Review. PubMed PMID: 19821407; PubMed Central PMCID: PMC4171124.

11: Mazières B. Topical ketoprofen patch. Drugs R D. 2005;6(6):337-44. Review. PubMed PMID: 16274258.

12: Mullangi R, Yao M, Srinivas NR. Resolution of enantiomers of ketoprofen by HPLC: a review. Biomed Chromatogr. 2003 Oct;17(7):423-34. Review. PubMed PMID: 14598325.

13: Veyrac G, Paulin M, Milpied B, Bourin M, Jolliet P. [Results of a French nationwide survey of cutaneous side effects of ketoprofen gel reported between September 1996 and August 2000]. Therapie. 2002 Jan-Feb;57(1):55-64. Review. French. PubMed PMID: 12090148.

14: Ouchi A, Zandomeneghi G, Zandomeneghi M. Complexation with albumins of chiral aromatic substrates and their chemistry in ground and excited states. Catalytic and chirality recognition properties of the protein in the cases of binaphthol, its photoisomers, and ketoprofen. Chirality. 2002 Jan;14(1):1-11. Review. PubMed PMID: 11748793.

15: Sugiura M, Hayakawa R, Kato Y, Sugiura K, Ueda H. 4 cases of photocontact dermatitis due to ketoprofen. Contact Dermatitis. 2000 Jul;43(1):16-9. Review. PubMed PMID: 10902583.

16: Schumacher HR Jr. Ketoprofen extended-release capsules: a new formulation for the treatment of osteoarthritis and rheumatoid arthritis. Clin Ther. 1994 Mar-Apr;16(2):145-59. Review. PubMed PMID: 8062310.

17: Serrano G, Fortea JM, Latasa JM, Millan F, Janes C, Bosca F, Miranda MA. Photosensitivity induced by fibric acid derivatives and its relation to photocontact dermatitis to ketoprofen. J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):204-8. Review. PubMed PMID: 1430357.

18: Jamali F, Brocks DR. Clinical pharmacokinetics of ketoprofen and its enantiomers. Clin Pharmacokinet. 1990 Sep;19(3):197-217. Review. PubMed PMID: 2203580.

19: Sunshine A, Olson NZ. Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. J Clin Pharmacol. 1988 Dec;28(12 Suppl):S47-54. Review. PubMed PMID: 3072358.

20: Williams RL, Upton RA. The clinical pharmacology of ketoprofen. J Clin Pharmacol. 1988 Dec;28(12 Suppl):S13-22. Review. PubMed PMID: 3072352.