WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206716
CAS#: 443989-01-3
Description: GSI-136 is a γ-Secretase Inhibitor. GSI-136 was developed by Wyeth (now a subsidiary of Pfizer) for AD treatment and evaluated in phase I clinical trials to determine its safety and tolerability in healthy subjects. The evaluation of this drug has been extended to other diseases. However, no information about the outcomes of the trials is presently available.
Hodoodo Cat#: H206716
Name: GSI-136
CAS#: 443989-01-3
Chemical Formula: C11H18ClNO3S2
Exact Mass: 311.04
Molecular Weight: 311.839
Elemental Analysis: C, 42.37; H, 5.82; Cl, 11.37; N, 4.49; O, 15.39; S, 20.56
This product is not in stock, which may be available by custom synthesis.
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Synonym: GSI-136; GSI 136; GSI136.
IUPAC/Chemical Name: (S)-5-chloro-N-(3-ethyl-1-hydroxypentan-2-yl)thiophene-2-sulfonamide
InChi Key: PYZFRRVBPNGCBX-SECBINFHSA-N
InChi Code: InChI=1S/C11H18ClNO3S2/c1-3-8(4-2)9(7-14)13-18(15,16)11-6-5-10(12)17-11/h5-6,8-9,13-14H,3-4,7H2,1-2H3/t9-/m1/s1
SMILES Code: O=S(C1=CC=C(Cl)S1)(N[C@@H](C(CC)CC)CO)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
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The following data is based on the product molecular weight 311.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |