WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526602
CAS#: 83843-39-4 (HCl)
Description: GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.
Hodoodo Cat#: H526602
Name: GYKI-23107 HCl
CAS#: 83843-39-4 (HCl)
Chemical Formula: C13H24Cl2N2
Exact Mass: 0.00
Molecular Weight: 279.250
Elemental Analysis: C, 55.92; H, 8.66; Cl, 25.39; N, 10.03
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Related CAS #: 83843-39-4 (HCl) 83843-49-6 (free base),
Synonym: GYKI-23107; GYKI 23107; GYKI23107; GYKI-23,107; GYKI 23,107; GYKI23,107; GYKI-23107 HCl.
IUPAC/Chemical Name: N1-(2,6-dimethylphenyl)-N2,N2-dimethylpropane-1,2-diamine dihydrochloride
InChi Key: OILXHOMZZDEACA-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H22N2.2ClH/c1-10-7-6-8-11(2)13(10)14-9-12(3)15(4)5;;/h6-8,12,14H,9H2,1-5H3;2*1H
SMILES Code: CC(N(C)C)CNC1=C(C)C=CC=C1C.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO, not in water | 0.0 | 100.00 |
The following data is based on the product molecular weight 279.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Varró A, Németh M, Rabloczky G, Papp JG, Szekeres L. Electrophysiological effects of GYKI-23 107, a new antiarrhythmic compound, in isolated rabbit and canine cardiac preparations. J Cardiovasc Pharmacol. 1988 Mar;11(3):251-7. PubMed PMID: 2452917.
2: Szatmary LJ, Rabloczky G, Kurthy M, Frater E, Solti F. Antifibrillatory effect of GYKI-23107 in induced ventricular vulnerability by local cooling and programmed stimulation in canine models. Acta Med Hung. 1988;45(2):221-9. PubMed PMID: 3247245.
3: Szatmary LJ, Rabloczky G, Kurthy M, Varro A, Solti F. Electrophysiological effects of the antiarrhythmic agent GYKI-23107 in dogs. Acta Med Hung. 1988;45(2):209-19. PubMed PMID: 3247244.
4: Varró A, Rabloczky G, Jaszlits L, Kürthy M, Zubovics Z, Toldy L. Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107. Drugs Exp Clin Res. 1987;13(1):21-8. PubMed PMID: 3595441.
