WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526609
CAS#: 185739-21-3 (free base)
Description: GYKI-16084 is a postsynaptic alpha2-blocker. GYKI-16084 may be potentially useful for the treatment of benign prostatic hyperplasia. The combined alpha1- and postsynaptically selective alpha2-blocker GYKI-16084 significantly improved the AUA symptom scores and increased Q(max) in patients with BPH, without inducing any adverse reaction, orthostatic changes or erectile dysfunction.
Hodoodo Cat#: H526609
Name: GYKI-16084
CAS#: 185739-21-3 (free base)
Chemical Formula: C16H19N3O3
Exact Mass: 301.14
Molecular Weight: 301.346
Elemental Analysis: C, 63.77; H, 6.36; N, 13.94; O, 15.93
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Synonym: GYKI-16084; GYKI 16084; GYKI16084.
IUPAC/Chemical Name: (R)-2-(3-(((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)amino)propyl)pyridazin-3(2H)-one
InChi Key: FJNRJBQUOQLUNQ-CYBMUJFWSA-N
InChi Code: InChI=1S/C16H19N3O3/c20-16-7-3-9-18-19(16)10-4-8-17-11-13-12-21-14-5-1-2-6-15(14)22-13/h1-3,5-7,9,13,17H,4,8,10-12H2/t13-/m1/s1
SMILES Code: O=C1C=CC=NN1CCCNC[C@H]2OC3=CC=CC=C3OC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# CAS No. 185739-21-3 (GYKI-16084 Free) 859838-08-7 (GYKI-16084 hydrochloride)
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The following data is based on the product molecular weight 301.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
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In vivo protocol: |