WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208390
CAS#: unknown
Description: EML108 is a Type 1 inhibitor of PMRT. EM108 was able to prevent arginine methylation of cellular proteins in whole-cell assays, with activities comparable to AMI-1
Hodoodo Cat#: H208390
Name: EML108
CAS#: unknown
Chemical Formula: C23H16N2O7
Exact Mass: 432.10
Molecular Weight: 432.390
Elemental Analysis: C, 63.89; H, 3.73; N, 6.48; O, 25.90
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: EML-108, eml108
IUPAC/Chemical Name: 6,6'-(Carbonylbis(azanediyl))bis(4-hydroxy-2-naphthoic acid)
InChi Key: SIWVJBJPYHPOMC-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H16N2O7/c26-19-7-13(21(28)29)5-11-1-3-15(9-17(11)19)24-23(32)25-16-4-2-12-6-14(22(30)31)8-20(27)18(12)10-16/h1-10,26-27H,(H,28,29)(H,30,31)(H2,24,25,32)
SMILES Code: O=C(NC1=CC2=C(O)C=C(C(O)=O)C=C2C=C1)NC3=CC4=C(O)C=C(C(O)=O)C=C4C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 432.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Giulia Iannelli, Ciro Milite, Nils Marechal, Vincent Cura, Luc Bonnefond, Nathalie Troffer-Charlier, Alessandra Feoli, Donatella Rescigno, Yalong Wang, Alessandra Cipriano, Monica Viviano, Mark T. Bedford, Jean Cavarelli, Sabrina Castellano, and Gianluca Sbardella
Journal of Medicinal Chemistry Article ASAP
DOI: 10.1021/acs.jmedchem.2c00252
