WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525743
CAS#: 1212-37-9 (iodide)
Description: Neostigmine Iodide is a parasympathomimetic compound that acts as a reversible acetylcholinesterase inhibitor. It is used to improve muscle tone in people with myasthenia gravis and routinely in anesthesia to reverse the effects of non-depolarizing muscle relaxants such as rocuronium and vecuronium at the end of an operation, usually in a dose of 25 to 50 μg per kilogram. It can also be used for urinary retention resulting from general anesthesia and to treat curariform drug toxicity.
Hodoodo Cat#: H525743
Name: Neostigmine Iodide
CAS#: 1212-37-9 (iodide)
Chemical Formula: C12H19IN2O2
Exact Mass: 350.05
Molecular Weight: 350.200
Elemental Analysis: C, 41.16; H, 5.47; I, 36.24; N, 8.00; O, 9.14
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Related CAS #: 59-99-4 (cation) 114-80-7 (bromide) 51-60-5 (methylsulfate) 1212-37-9 (iodide) 588-17-0 (hydroxide)
Synonym: SB-24; SB24; SB 24; TL-1321; TL 1321; TL1321; Neostigmine Iodide
IUPAC/Chemical Name: 3-((dimethylcarbamoyl)oxy)-N,N,N-trimethylbenzenaminium iodide
InChi Key: IRBBYXNXNPIQLI-UHFFFAOYSA-M
InChi Code: InChI=1S/C12H19N2O2.HI/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
SMILES Code: C[N+](C)(C1=CC=CC(OC(N(C)C)=O)=C1)C.[I-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 350.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sen A, Erdivanli B, Tomak Y, Pergel A. Reversal of neuromuscular blockade with sugammadex or neostigmine/atropine: Effect on postoperative gastrointestinal motility. J Clin Anesth. 2016 Aug;32:208-13. doi: 10.1016/j.jclinane.2016.03.010. Epub 2016 Apr 20. PubMed PMID: 27290978.
2: Sharma A, Kumar NJ, Azharuddin M, Mohan LC, Ramachandran G. Evaluation of low-dose dexmedetomidine and neostigmine with bupivacaine for postoperative analgesia in orthopedic surgeries: A prospective randomized double-blind study. J Anaesthesiol Clin Pharmacol. 2016 Apr-Jun;32(2):187-91. doi: 10.4103/0970-9185.173355. PubMed PMID: 27275047; PubMed Central PMCID: PMC4874072.
3: Berkó S, Szűcs KF, Balázs B, Csányi E, Varju G, Sztojkov-Ivanov A, Budai-Szűcs M, Bóta J, Gáspár R. Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration. Drug Des Devel Ther. 2016 May 19;10:1695-701. doi: 10.2147/DDDT.S102959. eCollection 2016. PubMed PMID: 27274203; PubMed Central PMCID: PMC4876850.
4: Wu J, Jin T, Wang H, Li ST. Sepsis Strengthens Antagonistic Actions of Neostigmine on Rocuronium in a Rat Model of Cecal Ligation and Puncture. Chin Med J (Engl). 2016 20th Jun;129(12):1477-1482. doi: 10.4103/0366-6999.183420. PubMed PMID: 27270546; PubMed Central PMCID: PMC4910374.
5: Martin-Flores M, Lorenzutti AM, Litterio NJ, Rossetti VL, Zarazaga MP, Bonetto CC, Aguirre GE. Speed of reversal of vecuronium neuromuscular block with different doses of neostigmine in anesthetized dogs. Vet Anaesth Analg. 2016 Jun 3. doi: 10.1111/vaa.12395. [Epub ahead of print] PubMed PMID: 27258375.
6: Iwasai S, Kinoshita Y, Asagoe Y, Matsuzaki T, Arai M, Sato T. [Anaphylactoid Reactions Suspected to Be Caused by Neostigmine in Pediatric Patients under General Anesthesia]. Masui. 2016 Apr;65(4):377-9. Japanese. PubMed PMID: 27188110.
7: Preault A, Capron F, Chantereau C, Donati F, Dimet J. Under sevoflurane anaesthesia, a reduced dose of neostigmine can antagonize a shallow neuromuscular block: A double-blind, randomised study. Anaesth Crit Care Pain Med. 2016 Apr 27. pii: S2352-5568(16)30026-1. doi: 10.1016/j.accpm.2015.11.008. [Epub ahead of print] PubMed PMID: 27131419.
8: Liu J, Cheng Z. [Comparison of neostigmine induced reversal of rocuronium in different age children]. Zhonghua Yi Xue Za Zhi. 2016 Mar 15;96(10):807-11. doi: 10.3760/cma.j.issn.0376-2491.2016.10.012. Chinese. PubMed PMID: 27055643.
9: Bhar D, RoyBasunia S, Das A, Kundu SB, Mondal RC, Halder PS, Mandal SK, Chattopadhyay S. A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study. Saudi J Anaesth. 2016 Apr-Jun;10(2):121-6. doi: 10.4103/1658-354X.168797. PubMed PMID: 27051359; PubMed Central PMCID: PMC4799600.
10: Stourac P, Adamus M, Seidlova D, Pavlik T, Janku P, Krikava I, Mrozek Z, Prochazka M, Klucka J, Stoudek R, Bartikova I, Kosinova M, Harazim H, Robotkova H, Hejduk K, Hodicka Z, Kirchnerova M, Francakova J, Obare Pyszkova L, Hlozkova J, Sevcik P. Low-Dose or High-Dose Rocuronium Reversed with Neostigmine or Sugammadex for Cesarean Delivery Anesthesia: A Randomized Controlled Noninferiority Trial of Time to Tracheal Intubation and Extubation. Anesth Analg. 2016 May;122(5):1536-45. doi: 10.1213/ANE.0000000000001197. PubMed PMID: 26974018.
11: Isik Y, Palabiyik O, Cegin BM, Goktas U, Kati I. Effects of Sugammadex and Neostigmine on Renal Biomarkers. Med Sci Monit. 2016 Mar 10;22:803-9. PubMed PMID: 26963316; PubMed Central PMCID: PMC4791087.
12: Dodds MM, Frazer CD, Lipman J, Reade M. Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. Crit Care Resusc. 2016 Mar;18(1):59-61. PubMed PMID: 26947418.
13: Hakimoğlu S, Tuzcu K, Davarcı I, Karcıoğlu M, Ayhan Tuzcu E, Hancı V, Aydın S, Kahraman H, Elbeyli A, Turhanoğlu S. Comparison of sugammadex and neostigmine-atropine on intraocular pressure and postoperative effects. Kaohsiung J Med Sci. 2016 Feb;32(2):80-5. doi: 10.1016/j.kjms.2016.01.009. Epub 2016 Feb 23. PubMed PMID: 26944326.
14: Patil SA, Bokoliya SC, Nagappa M, Taly AB. Diagnosis of myasthenia gravis: Comparison of anti-nicotinic acetyl choline receptor antibodies, repetitive nerve stimulation and Neostigmine tests at a tertiary neuro care centre in India, a ten year study. J Neuroimmunol. 2016 Mar 15;292:81-4. doi: 10.1016/j.jneuroim.2016.01.006. Epub 2016 Jan 20. PubMed PMID: 26943963.
15: Pyo JH, Min YW, Rhee PL. Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. Korean J Gastroenterol. 2016 Feb;67(2):103-6. doi: 10.4166/kjg.2016.67.2.103. PubMed PMID: 26907487.
16: Choi ES, Oh AY, Seo KS, Hwang JW, Ryu JH, Koo BW, Kim BG. Optimum dose of neostigmine to reverse shallow neuromuscular blockade with rocuronium and cisatracurium. Anaesthesia. 2016 Apr;71(4):443-9. doi: 10.1111/anae.13398. Epub 2016 Feb 13. PubMed PMID: 26874258.
17: Fogaça MV, Fedoce AG, Ferreira-Junior NC, Guimarães FS, Resstel LB. Involvement of M1 and CB1 receptors in the anxiogenic-like effects induced by neostigmine injected into the rat prelimbic medial prefrontal cortex. Psychopharmacology (Berl). 2016 Apr;233(8):1377-85. doi: 10.1007/s00213-016-4228-7. Epub 2016 Feb 13. PubMed PMID: 26873081.
18: Mouchli MA, Camilleri M, Lee T, Parthasarathy G, Vijayvargiya P, Halland M, Acosta A, Bharucha AE. Evaluating the safety and the effects on colonic compliance of neostigmine during motility testing in patients with chronic constipation. Neurogastroenterol Motil. 2016 Jun;28(6):871-8. doi: 10.1111/nmo.12786. Epub 2016 Feb 3. PubMed PMID: 26840188; PubMed Central PMCID: PMC4877263.
19: Kizilay D, Dal D, Saracoglu KT, Eti Z, Gogus FY. Comparison of neostigmine and sugammadex for hemodynamic parameters in cardiac patients undergoing noncardiac surgery. J Clin Anesth. 2016 Feb;28:30-5. doi: 10.1016/j.jclinane.2015.08.002. Epub 2015 Nov 11. PubMed PMID: 26796612.
20: Kaufhold N, Schaller SJ, Stäuble CG, Baumüller E, Ulm K, Blobner M, Fink H. Sugammadex and neostigmine dose-finding study for reversal of residual neuromuscular block at a train-of-four ratio of 0.2 (SUNDRO20)†,. Br J Anaesth. 2016 Feb;116(2):233-40. doi: 10.1093/bja/aev437. PubMed PMID: 26787792.
