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Florfenicol
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H525064

CAS#: 73231-34-2

Description: Florfenicol is a fluorinated synthetic analog of thiamphenicol , mainly used in veterinary medicine. It is used for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon.

Chemical Structure

Florfenicol

CAS# 73231-34-2

Instruction

Theoretical Analysis

Hodoodo Cat#: H525064
Name: Florfenicol
CAS#: 73231-34-2
Chemical Formula: C12H14Cl2FNO4S
Exact Mass: 357.00
Molecular Weight: 358.210
Elemental Analysis: C, 40.24; H, 3.94; Cl, 19.79; F, 5.30; N, 3.91; O, 17.87; S, 8.95

Price and Availability

Size	Price	Availability
1g	USD 250	2 Weeks
5g	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Florfenicol; Nuflor; Sch-25298; Sch25298; Sch 25298; (-)-Florfenicol; Aquafen; thiamphenicol, 3-fluoro.

IUPAC/Chemical Name: Acetamide, 2,2-dichloro-N-((1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-

InChi Key: AYIRNRDRBQJXIF-NXEZZACHSA-N

InChi Code: InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1

SMILES Code: CS(=O)(=O)c1ccc(cc1)[C@H]([C@@H](CF)NC(=O)C(Cl)Cl)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 358.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sandoval R, Oliver C, Valdivia S, Valenzuela K, Haro RE, Sánchez P, Olavarría VH, Valenzuela P, Avendaño-Herrera R, Romero A, Cárcamo JG, Figueroa JE, Yáñez AJ. Resistance-nodulation-division efflux pump acrAB is modulated by florfenicol and contributes to drug resistance in the fish pathogen Piscirickettsia salmonis. FEMS Microbiol Lett. 2016 Jun;363(11). pii: fnw102. doi: 10.1093/femsle/fnw102. Epub 2016 Apr 15. PubMed PMID: 27190287.

2: Kawalek JC, Howard KD, Jones Y, Scott ML, Myers MJ. Depletion of florfenicol in lactating dairy cows after intramammary and subcutaneous administration. J Vet Pharmacol Ther. 2016 May 18. doi: 10.1111/jvp.12315. [Epub ahead of print] PubMed PMID: 27189015.

3: Wang Z, Wang S, Peijnenburg WJ. Prediction of joint algal toxicity of nano-CeO2/nano-TiO2 and florfenicol: Independent action surpasses concentration addition. Chemosphere. 2016 Aug;156:8-13. doi: 10.1016/j.chemosphere.2016.04.072. Epub 2016 May 6. PubMed PMID: 27156210.

4: Barreto F, Ribeiro C, Barcellos Hoff R, Dalla Costa T. Determination of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in poultry, swine, bovine and fish by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2016 Jun 3;1449:48-53. doi: 10.1016/j.chroma.2016.04.024. Epub 2016 Apr 16. PubMed PMID: 27133862.

5: Mosleh N, Shomali T, Namazi F, Marzban M, Mohammadi M, Boroojeni AM. Comparative evaluation of therapeutic efficacy of sulfadiazine-trimethoprim, oxytetracycline, enrofloxacin and florfenicol on Staphylococcus aureus-induced arthritis in broilers. Br Poult Sci. 2016 Apr;57(2):179-84. doi: 10.1080/00071668.2016.1148263. PubMed PMID: 27111299.

6: Wei CF, Shien JH, Chang SK, Chou CC. Florfenicol As a Modulator Enhancing Antimicrobial Activity: Example Using Combination with Thiamphenicol against Pasteurella multocida. Front Microbiol. 2016 Mar 30;7:389. doi: 10.3389/fmicb.2016.00389. eCollection 2016. PubMed PMID: 27065961; PubMed Central PMCID: PMC4811925.

7: Faulkner D, Cantley M, Walker M, Crooks S, Kennedy D, Elliott C. Evidence of non-extractable florfenicol residues: development and validation of a confirmatory method for total florfenicol content in kidney by UPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jun;33(6):983-94. doi: 10.1080/19440049.2016.1175187. Epub 2016 May 20. PubMed PMID: 27053017.

8: Li X, Xie S, Pan Y, Qu W, Tao Y, Chen D, Huang L, Liu Z, Wang Y, Yuan Z. Preparation, characterization and pharmacokinetics of doxycycline hydrochloride and florfenicol polyvinylpyrroliddone microparticle entrapped with hydroxypropyl-β-cyclodextrin inclusion complexes suspension. Colloids Surf B Biointerfaces. 2016 May 1;141:634-42. doi: 10.1016/j.colsurfb.2016.02.027. Epub 2016 Feb 12. PubMed PMID: 26918512.

9: Foster DM, Martin LG, Papich MG. Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or Tulathromycin. PLoS One. 2016 Feb 12;11(2):e0149100. doi: 10.1371/journal.pone.0149100. eCollection 2016. PubMed PMID: 26872361; PubMed Central PMCID: PMC4752255.

10: Wei CF, Chang SK, Shien JH, Kuo HC, Chen WY, Chou CC. Synergism between two amphenicol of antibiotics, florfenicol and thiamphenicol, against Staphylococcus aureus. Vet Rec. 2016 Mar 26;178(13):319. doi: 10.1136/vr.103554. Epub 2016 Feb 10. PubMed PMID: 26864028.

11: Liu HY, Lin SL, Fuh MR. Determination of chloramphenicol, thiamphenicol and florfenicol in milk and honey using modified QuEChERS extraction coupled with polymeric monolith-based capillary liquid chromatography tandem mass spectrometry. Talanta. 2016 Apr 1;150:233-9. doi: 10.1016/j.talanta.2015.12.045. Epub 2015 Dec 18. PubMed PMID: 26838404.

12: Sadeghi S, Jahani M, Belador F. The development of a new optical sensor based on the Mn doped ZnS quantum dots modified with the molecularly imprinted polymers for sensitive recognition of florfenicol. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 15;159:83-9. doi: 10.1016/j.saa.2016.01.043. Epub 2016 Jan 25. PubMed PMID: 26828536.

13: Zhang Y, Li J, Zhou L, Wang G, Feng Y, Wang Z, Yang X. Aqueous photodegradation of antibiotic florfenicol: kinetics and degradation pathway studies. Environ Sci Pollut Res Int. 2016 Apr;23(7):6982-9. doi: 10.1007/s11356-015-5897-1. Epub 2015 Dec 26. PubMed PMID: 26705756.

14: Wang T, Chen X, Lu M, Li X, Zhou W. Preparation, characterisation and antibacterial activity of a florfenicol-loaded solid lipid nanoparticle suspension. IET Nanobiotechnol. 2015 Dec;9(6):355-61. doi: 10.1049/iet-nbt.2015.0012. PubMed PMID: 26647811.

15: Oultram J, Phipps E, Teixeira AG, Foditsch C, Bicalho ML, Machado VS, Bicalho RC, Oikonomou G. Effects of antibiotics (oxytetracycline, florfenicol or tulathromycin) on neonatal calves' faecal microbial diversity. Vet Rec. 2015 Dec 12;177(23):598. doi: 10.1136/vr.103320. Epub 2015 Dec 8. PubMed PMID: 26645721.

16: Feng JB, Huang DR, Zhong M, Liu P, Dong JD. Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration. J Fish Dis. 2016 Jul;39(7):833-43. doi: 10.1111/jfd.12416. Epub 2015 Nov 3. PubMed PMID: 26525310.

17: Xiao Z, Song R, Rao Z, Wei S, Jia Z, Suo D, Fan X. Development of a subcritical water extraction approach for trace analysis of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in poultry tissues. J Chromatogr A. 2015 Oct 30;1418:29-35. doi: 10.1016/j.chroma.2015.09.047. Epub 2015 Sep 24. PubMed PMID: 26433266.

18: Blondeau JM, Shebelski SD, Hesje CK. Bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica. Am J Vet Res. 2015 Oct;76(10):860-8. doi: 10.2460/ajvr.76.10.860. PubMed PMID: 26413823.

19: Black LA, Higgins DP, Govendir M. In vitro activity of chloramphenicol, florfenicol and enrofloxacin against Chlamydia pecorum isolated from koalas (Phascolarctos cinereus). Aust Vet J. 2015 Nov;93(11):420-3. doi: 10.1111/avj.12364. Epub 2015 Sep 27. PubMed PMID: 26412342.

20: Gaunt PS, Chatakondi N, Gao D, Endris R. Efficacy of Florfenicol for Control of Mortality Associated with Edwardsiella ictaluri in Three Species of Catfish. J Aquat Anim Health. 2015 Mar;27(1):45-9. PubMed PMID: 26306332.