WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130509
CAS#: 1418293-40-9 (free base)
Description: NT160 is highly potent class-IIa histone deacetylase probe. Radio-labed [18F]-NT160 is a diagnostic tool for positron emission tomography (PET). [18F]-NT160 can cross the blood brain barrier and bind to class-IIa HDACs in vivo. PET imaging with [18F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast images of the brain. [18F]NT160 displayed excellent pharmacokinetic and imaging characteristics: brain uptake is high in gray matter regions, tissue kinetics are appropriate for a 18F-tracer, and specific binding for class-IIa HDACs is demonstrated by self-blockade. Note: This product we are supplying is not radiolabeled.
Hodoodo Cat#: H130509
Name: NT160
CAS#: 1418293-40-9 (free base)
Chemical Formula: C21H21F3N4O2
Exact Mass: 418.16
Molecular Weight: 418.420
Elemental Analysis: C, 60.28; H, 5.06; F, 13.62; N, 13.39; O, 7.65
Related CAS #: 1418293-40-9 (free base) NT160 HCl
Synonym: NT 160, NT-160, (R)-N-(1-(Benzyl(methyl)amino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
IUPAC/Chemical Name: (R)-N-(1-(Benzyl(methyl)amino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
InChi Key: RESDVUQVZOJNSO-CQSZACIVSA-N
InChi Code: InChI=1S/C21H21F3N4O2/c1-14(12-28(2)13-15-6-4-3-5-7-15)25-19(29)17-10-8-16(9-11-17)18-26-20(30-27-18)21(22,23)24/h3-11,14H,12-13H2,1-2H3,(H,25,29)/t14-/m1/s1
SMILES Code: O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 418.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Turkman N, Xu S, Huang CH, Eyermann C, Salino J, Khan P. High-Contrast PET Imaging with [18F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System. J Med Chem. 2023 Apr 27;66(8):5611-5621. doi: 10.1021/acs.jmedchem.2c02064. Epub 2023 Apr 17. PMID: 37068265; PMCID: PMC10150721.
2. Turkman N, Liu D, Pirola I. Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy. Eur J Med Chem. 2022 Jan 15;228:114011. doi: 10.1016/j.ejmech.2021.114011. Epub 2021 Dec 2. PMID: 34875522; PMCID: PMC8919062.
