WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130510
CAS#: NT160 HCl
Description: NT160 is highly potent class-IIa histone deacetylase probe. Radio-labed [18F]-NT160 is a diagnostic tool for positron emission tomography (PET). [18F]-NT160 can cross the blood brain barrier and bind to class-IIa HDACs in vivo. PET imaging with [18F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast images of the brain. [18F]NT160 displayed excellent pharmacokinetic and imaging characteristics: brain uptake is high in gray matter regions, tissue kinetics are appropriate for a 18F-tracer, and specific binding for class-IIa HDACs is demonstrated by self-blockade. Note: This product we are supplying is not radiolabeled.
Hodoodo Cat#: H130510
Name: NT160 HCl
CAS#: NT160 HCl
Chemical Formula: C21H22ClF3N4O2
Exact Mass: 0.00
Molecular Weight: 454.878
Elemental Analysis: C, 55.45; H, 4.88; Cl, 7.79; F, 12.53; N, 12.32; O, 7.03
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1418293-40-9 (free base) NT160 HCl
Synonym: NT160 HCl; NT160 hydrochloride, NT 160; NT-160; NT160;
IUPAC/Chemical Name: (R)-N-(1-(Benzyl(methyl)amino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide hydrochloride
InChi Key: NUHXHKRXVDGRNM-PFEQFJNWSA-N
InChi Code: InChI=1S/C21H21F3N4O2.ClH/c1-14(12-28(2)13-15-6-4-3-5-7-15)25-19(29)17-10-8-16(9-11-17)18-26-20(30-27-18)21(22,23)24;/h3-11,14H,12-13H2,1-2H3,(H,25,29);1H/t14-;/m1./s1
SMILES Code: O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2.[H]Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 454.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |