WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561647
CAS#: 6119-70-6 (sulfate dihydrate)
Description: Quinine sulfate dihydrate is an antimalarial agent. It works by reducing oxygen intake and carbohydrate metabolism, disrupting DNA replication and transcription via DNA intercalation, and reducing excitability of muscle fibers via alteration of calcium distribution. It is also an inhibitor of P-glycoprotein.
Hodoodo Cat#: H561647
Name: Quinine sulfate dihydrate
CAS#: 6119-70-6 (sulfate dihydrate)
Chemical Formula: C20H28N2O7S
Exact Mass: 0.00
Molecular Weight: 440.510
Elemental Analysis: C, 54.53; H, 6.41; N, 6.36; O, 25.42; S, 7.28
Related CAS #: 60-93-5 (2HCl) 6119-70-6 (sulfate dihydrate) 804-63-7 (sulfate) 130-95-0 (free base) 60-93-5 (2HCl) 6119-70-6 (sulfate dihydrate) 804-63-7 (sulfate) 130-95-0 (free base) 549-49-5 (HBr)
Synonym: Quinine sulfate dihydrate; Chinini sulfas; Quinine hemisulfate salt monohydrate;
IUPAC/Chemical Name: (1R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol hemisulfate hydrate
InChi Key: ZYCWGZVLCXRARB-HZQSTTLBSA-N
InChi Code: InChI=1S/C20H24N2O2.H2O4S.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);1H2/t13-,14-,19-,20+;;/m0../s1
SMILES Code: O[C@@H]([C@H]1N(CC2)C[C@H](C=C)[C@]2([H])C1)C3=CC=NC4=CC=C(OC)C=C34.O=S(O)(O)=O.O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 440.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Würth C, Grabolle M, Pauli J, Spieles M, Resch-Genger U. Comparison of methods and achievable uncertainties for the relative and absolute measurement of photoluminescence quantum yields. Anal Chem. 2011 May 1;83(9):3431-9. doi: 10.1021/ac2000303. Epub 2011 Apr 7. PubMed PMID: 21473570.
2: Würth C, Lochmann C, Spieles M, Pauli J, Hoffmann K, Schüttrigkeit T, Franzl T, Resch-Genger U. Evaluation of a commercial integrating sphere setup for the determination of absolute photoluminescence quantum yields of dilute dye solutions. Appl Spectrosc. 2010 Jul;64(7):733-41. doi: 10.1366/000370210791666390. PubMed PMID: 20615286.
3: Mangwala Kimpende P, Van Meervelt L. Redetermination of bis-{(1S,2S,4S,5R)-2-[(R)-hy-droxy(6-meth-oxy-4-quinol-yl)meth-yl]-5-vinyl-quinuc lidinium} sulfate dihydrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 28;66(Pt 9):o2443-4. doi: 10.1107/S1600536810034288. PubMed PMID: 21588765; PubMed Central PMCID: PMC3008057.
4: Fluorescence standard reference material: quinine sulfate dihydrate. Appl Opt. 1981 May 1;20(9):1718. PubMed PMID: 20309374.