Dicarboxidine

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Hodoodo CAT#: H592537

CAS#: 34915-18-9 (free base)

Description: Dicarboxidine is a chromogen for the detection of barbiturates, meprobamate and some other sedatives on thin-layer chromatograms. Dicarboxidine is a safe substitute for conventional benzidine type reagents. Dicarboxidine can be used for detection of N-Boc-protected amino acids and peptides by TLC. Dicarboxidine is a substrate for peroxidases as horse radish peroxidase.

Chemical Structure

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Dicarboxidine
CAS# 34915-18-9 (free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H592537
Name: Dicarboxidine
CAS#: 34915-18-9 (free base)
Chemical Formula: C20H24N2O6
Exact Mass: 388.16
Molecular Weight: 388.420
Elemental Analysis: C, 61.85; H, 6.23; N, 7.21; O, 24.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 56455-90-4 (HCl)   34915-18-9 (free base)    

Synonym: Dicarboxidine

IUPAC/Chemical Name: Butanoic acid, 4,4'-((4,4'-diamino(1,1'-biphenyl)-3,3'-diyl)bis(oxy))bis-

InChi Key: NUBOMXHHTQFVBI-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24N2O6/c21-15-7-5-13(11-17(15)27-9-1-3-19(23)24)14-6-8-16(22)18(12-14)28-10-2-4-20(25)26/h5-8,11-12H,1-4,9-10,21-22H2,(H,23,24)(H,25,26)

SMILES Code: NC1=CC=C(C2=CC=C(N)C(OCCCC(O)=O)=C2)C=C1OCCCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 388.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen R, Li TM, Merrick H, Parrish RF, Bruno V, Kwong A, Stiso C, Litman DJ. An internal clock reaction used in a one-step enzyme immunochromatographic assay of theophylline in whole blood. Clin Chem. 1987 Sep;33(9):1521-5. PubMed PMID: 3304712.

2: Paul KG, Ohlsson PI, Jönsson NA. The assay of peroxidases by means of dicarboxidine on enzyme-linked immunosorbent assay level. Anal Biochem. 1982 Jul 15;124(1):102-7. PubMed PMID: 7125217.

3: Swolin B, Roberts D, Waldenström J. Quantitative determination of plasma hemoglobin using dicarboxidine. Clin Chim Acta. 1982 Jun 3;121(3):389-91. PubMed PMID: 7105402.

4: Svahn CM, Gyllander J. Dicarboxidine [gamma, gamma'-(4,4'-diamino-3,3'-biphenylylenedioxy)dibutyric acid] dihydrochloride as a chromogen for the detection of barbiturates, meprobamate and some other sedatives on thin-layer chromatograms. J Chromatogr. 1979 Feb 11;170(1):294-5. PubMed PMID: 544628.

5: Jönsson NA, Gröningsson K, Pavlu B, Vessman J, Westlund LE. gamma,gamma'-(4,4'-Diamino-3,3'-biphenylylenedioxy)dibutyric acid (dicarboxidine) a safer substitute for benzidine type chromogens. Arzneimittelforschung. 1979;29(2):187-93. PubMed PMID: 582129.

6: Pliss GB, Vol'fson NI. [Possible carcinogenic action of chromogen dicarboxidine]. Vopr Onkol. 1979;25(7):43-8. Russian. PubMed PMID: 483680.