WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412828
CAS#: 1668-99-1 (HCl)
Description: Quinidine hydrochloride is the salt form of Qunidine, and Antiarrhythmic and Anti-parasite. It can treat certain kinds of irregular heartbeats (arrhythmias). It can also treat malaria.
Hodoodo Cat#: H412828
Name: Quinidine hydrochloride
CAS#: 1668-99-1 (HCl)
Chemical Formula: C20H25ClN2O2
Exact Mass: 360.16
Molecular Weight: 360.880
Elemental Analysis: C, 66.56; H, 6.98; Cl, 9.82; N, 7.76; O, 8.87
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 747-45-5 (bisulfate) 27555-34-6 (polygalacturonate) 56-54-2 (free base) 1668-99-1 (HCl) 7054-25-3 (gluconate)
Synonym: Quinidine hydrochloride; EINECS 216-792-8; Quinidine HCl
IUPAC/Chemical Name: (1S)-(6-methoxyquinolin-4-yl)((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride
InChi Key: LBSFSRMTJJPTCW-VJAUXQICSA-N
InChi Code: InChI=1S/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19+,20-;/m0./s1
SMILES Code: COc(cc1)cc2c1nccc2[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
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The following data is based on the product molecular weight 360.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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2: Vitali Serdoz L, Rittger H, Furlanello F, Bastian D. Quinidine-A legacy within the modern era of antiarrhythmic therapy. Pharmacol Res. 2019 Jun;144:257-263. doi: 10.1016/j.phrs.2019.04.028. Epub 2019 Apr 23. PMID: 31026503.
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4: Yang F, Hanon S, Lam P, Schweitzer P. Quinidine revisited. Am J Med. 2009 Apr;122(4):317-21. doi: 10.1016/j.amjmed.2008.11.019. Epub 2009 Feb 25. PMID: 19249010.
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6: BAROODY WG, BAROODY NB. Quinidine. Med Times. 1960 Aug;88:962-5. PMID: 13797001.
7: Luo C, Whittaker DG, Liu T, Wang K, Li Y, He Y, Zhang H. Pharmacotherapeutic Effects of Quinidine on Short QT Syndrome by Using Purkinje-Ventricle Model: A Simulation Study. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:2856-2859. doi: 10.1109/EMBC.2019.8857134. PMID: 31946488.
8: Ochs HR, Greenblatt DJ, Woo E. Clinical pharmacokinetics of quinidine. Clin Pharmacokinet. 1980 Mar-Apr;5(2):150-68. doi: 10.2165/00003088-198005020-00003. PMID: 6988137.
9: Che Z, Yang J, Sun D, Tian Y, Liu S, Lin X, Jiang J, Chen G. Synthesis of Novel (9S)-Acyloxy Derivatives of Quinidine and Dihydroquinidine as Insecticidal Agents. Chem Biodivers. 2020 Apr;17(4):e1900696. doi: 10.1002/cbdv.201900696. Epub 2020 Mar 30. PMID: 32134169.
10: Malcolm AD, David GK. Quinidine in cardiology. Acta Leiden. 1987;55:87-98. PMID: 3321844.
