WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H414248
CAS#: 747-45-5 (bisulfate)
Description: Quinidine bisulfate is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart.
Hodoodo Cat#: H414248
Name: Quinidine bisulfate
CAS#: 747-45-5 (bisulfate)
Chemical Formula: C20H26N2O6S
Exact Mass: 0.00
Molecular Weight: 422.490
Elemental Analysis: C, 56.86; H, 6.20; N, 6.63; O, 22.72; S, 7.59
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 747-45-5 (bisulfate) 27555-34-6 (polygalacturonate) 56-54-2 (free base) 1668-99-1 (HCl) 7054-25-3 (gluconate)
Synonym: Quinidine bisulfate; Biquin durules; Chinidin VUFB; Kinilentin; Optochinidin
IUPAC/Chemical Name: Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate (1:1)
InChi Key: AKYHKWQPZHDOBW-VJAUXQICSA-N
InChi Code: InChI=1S/C20H24N2O2.H2O4S/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t13-,14-,19+,20-;/m0./s1
SMILES Code: C=C[C@@H](C[N@@]1CC2)[C@@H]2C[C@@H]1[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.O=S(O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 422.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Belhassen B, Glick A, Viskin S. Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation. 2004 Sep 28;110(13):1731-7. doi: 10.1161/01.CIR.0000143159.30585.90. Epub 2004 Sep 20. PMID: 15381640.
2: Olsson G. To the editor--Market withdrawal of quinidine bisulfate (Kinidin Durules) in 2006. Heart Rhythm. 2010 Jun;7(6):864. doi: 10.1016/j.hrthm.2010.03.010. Epub 2010 Mar 10. PMID: 20226273.
3: Jamaludin A, Mohamed M, Navaratnam V, Mohamed N, Yeoh E, Wernsdorfer W. Single-dose comparative kinetics and bioavailability study of quinine hydrochloride, quinidine sulfate and quinidine bisulfate sustained-release in healthy male volunteers. Acta Leiden. 1988;57(1):39-46. PMID: 3245401.
4: Mahon WA, Mayersohn M, Inaba T. Disposition kinetics of two oral forms of quinidine. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):566-75. doi: 10.1002/cpt1976195part1566. PMID: 1277713.
5: Bottorff MB, Lalonde RL, Straughn AB. Comparison of high pressure liquid chromatography and fluorescence polarization immunoassay to assess quinidine pharmacokinetics. Biopharm Drug Dispos. 1987 May-Jun;8(3):213-21. doi: 10.1002/bdd.2510080303. PMID: 3297181.
6: Remon JP, Belpaire F, Van Severen R, Braeckman P. Interaction of antacids with antiarrhythmics. V. Effect of aluminium hydroxide and magnesium oxide on the bioavailability of quinidine, procainamide and propranolol in dogs. Arzneimittelforschung. 1983;33(1):117-20. PMID: 6681962.
7: Hii JT, Wyse DG, Gillis AM, Cohen JM, Mitchell LB. Propafenone-induced torsade de pointes: cross-reactivity with quinidine. Pacing Clin Electrophysiol. 1991 Nov;14(11 Pt 1):1568-70. doi: 10.1111/j.1540-8159.1991.tb02729.x. PMID: 1721143.
8: Huminer D, Dux S, Rosenfeld JB, Pitlik SD. Inadvertent sulfonylurea-induced hypoglycemia. A dangerous, but preventable condition. Arch Intern Med. 1989 Aug;149(8):1890-2. PMID: 2504124.
9: Rakhmanova MM, Sokolov SF. [Efficacy and safety of allapinine and quinidine bisulphate in the treatment of patients with persistent atrial fibrillation after cardioversion]. Kardiologiia. 2014;54(9):33-8. Russian. doi: 10.18565/cardio.2014.9.33-38. PMID: 25702400.
10: Knapp W, Lechleitner P. Relative Bioverfügbarkeit sowie Einfluss von Chindin in Form einer Retard-Zubereitung auf Blutdruck und EKG von gesunden Probanden [Relative bioavailability and influence of a quinidine retard-formulation on blood-pressure and ECG in healthy volunteers (author's transl)]. Arzneimittelforschung. 1981;31(9):1482-6. German. PMID: 7197960.