Tridihexethyl chloride

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Hodoodo CAT#: H318905

CAS#: 4310-35-4 (chloride)

Description: Tridihexethyl is an anticholinergic, antimuscarinic and antispasmodic drug. It may be used, usually in combination with other drugs, to treat acquired nystagmus or peptic ulcer disease.


Chemical Structure

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Tridihexethyl chloride
CAS# 4310-35-4 (chloride)

Theoretical Analysis

Hodoodo Cat#: H318905
Name: Tridihexethyl chloride
CAS#: 4310-35-4 (chloride)
Chemical Formula: C21H36ClNO
Exact Mass: 318.28
Molecular Weight: 353.975
Elemental Analysis: C, 71.26; H, 10.25; Cl, 10.01; N, 3.96; O, 4.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
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Related CAS #: 125-99-5 (iodide)   4310-35-4 (chloride)   60-49-1 (cation)    

Synonym: Tridihexethyl, Pathilon, Propethonum; Tridihexethyl chloride.

IUPAC/Chemical Name: 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium chloride

InChi Key: XJGONMZLEDGBRM-UHFFFAOYSA-M

InChi Code: InChI=1S/C21H36NO.ClH/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20;/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3;1H/q+1;/p-1

SMILES Code: OC(C1=CC=CC=C1)(C2CCCCC2)CC[N+](CC)(CC)CC.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 353.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ. Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41. PubMed PMID: 1944902.

2: Kirchhoefer RD. Semiautomated determination of tridihexethyl chloride in meprobamate tablets. J Assoc Off Anal Chem. 1984 Jul-Aug;67(4):677-8. PubMed PMID: 6469893.

3: Lippold BC, Lettenbauer WA. [The absorption of homologous alkyl sulphonates of tridihexethyl (author's transl)]. Pharmazie. 1980;35(10):612-20. German. PubMed PMID: 6256779.

4: Lippold BC, Lettenbauer WA. [Membrane diffusion of homologous organic salts of tridihexethyl]. Pharmazie. 1978 Apr;33(4):221-5. German. PubMed PMID: 674319.

5: GARCIAHERRERA E, GARCIAHERRERA A. [TREATMENT OF GASTROINTESTINAL SPASM IN THE CHILD WITH A SOLUTION OF TRIDIHEXETHYL CHLORIDE]. Medicina (Mex). 1963 Oct 10;43:475-80. Spanish. PubMed PMID: 14107303.

6: PHILLIPS FJ. Peptic ulcer: treatment with a combination of meprobamate and tridihexethyl chloride. Clin Med (Northfield). 1963 Jul;70:1303-6. PubMed PMID: 15445911.

7: OSTERBERG AC, GRAY WD. The anticholinergic actions of tridihexethyl iodide. Arch Int Pharmacodyn Ther. 1962 Jun 1;137:250-66. PubMed PMID: 14482588.

8: SLATER S, NUMEROFF M. Effect of meprobamate-tridihexethyl iodide on the uptake of radioactive iodine and on the serum protein-bound iodine. N Engl J Med. 1958 Nov 13;259(20):974-5. PubMed PMID: 13600606.