WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H318905
CAS#: 4310-35-4 (chloride)
Description: Tridihexethyl is an anticholinergic, antimuscarinic and antispasmodic drug. It may be used, usually in combination with other drugs, to treat acquired nystagmus or peptic ulcer disease.
Hodoodo Cat#: H318905
Name: Tridihexethyl chloride
CAS#: 4310-35-4 (chloride)
Chemical Formula: C21H36ClNO
Exact Mass: 318.28
Molecular Weight: 353.975
Elemental Analysis: C, 71.26; H, 10.25; Cl, 10.01; N, 3.96; O, 4.52
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Related CAS #: 125-99-5 (iodide) 4310-35-4 (chloride) 60-49-1 (cation)
Synonym: Tridihexethyl, Pathilon, Propethonum; Tridihexethyl chloride.
IUPAC/Chemical Name: 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium chloride
InChi Key: XJGONMZLEDGBRM-UHFFFAOYSA-M
InChi Code: InChI=1S/C21H36NO.ClH/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20;/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3;1H/q+1;/p-1
SMILES Code: OC(C1=CC=CC=C1)(C2CCCCC2)CC[N+](CC)(CC)CC.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 353.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ. Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41. PubMed PMID: 1944902.
2: Kirchhoefer RD. Semiautomated determination of tridihexethyl chloride in meprobamate tablets. J Assoc Off Anal Chem. 1984 Jul-Aug;67(4):677-8. PubMed PMID: 6469893.
3: Lippold BC, Lettenbauer WA. [The absorption of homologous alkyl sulphonates of tridihexethyl (author's transl)]. Pharmazie. 1980;35(10):612-20. German. PubMed PMID: 6256779.
4: Lippold BC, Lettenbauer WA. [Membrane diffusion of homologous organic salts of tridihexethyl]. Pharmazie. 1978 Apr;33(4):221-5. German. PubMed PMID: 674319.
5: GARCIAHERRERA E, GARCIAHERRERA A. [TREATMENT OF GASTROINTESTINAL SPASM IN THE CHILD WITH A SOLUTION OF TRIDIHEXETHYL CHLORIDE]. Medicina (Mex). 1963 Oct 10;43:475-80. Spanish. PubMed PMID: 14107303.
6: PHILLIPS FJ. Peptic ulcer: treatment with a combination of meprobamate and tridihexethyl chloride. Clin Med (Northfield). 1963 Jul;70:1303-6. PubMed PMID: 15445911.
7: OSTERBERG AC, GRAY WD. The anticholinergic actions of tridihexethyl iodide. Arch Int Pharmacodyn Ther. 1962 Jun 1;137:250-66. PubMed PMID: 14482588.
8: SLATER S, NUMEROFF M. Effect of meprobamate-tridihexethyl iodide on the uptake of radioactive iodine and on the serum protein-bound iodine. N Engl J Med. 1958 Nov 13;259(20):974-5. PubMed PMID: 13600606.