Cefovecin Sodium

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H524581

CAS#: 141195-77-9 (sodium)

Description: Cefovecin Sodium, also known as Convenia, is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner compliance with dosing for the animal. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus intermedius/S. canis in dogs.

Chemical Structure

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Cefovecin Sodium
CAS# 141195-77-9 (sodium)
Instruction

Theoretical Analysis

Hodoodo Cat#: H524581
Name: Cefovecin Sodium
CAS#: 141195-77-9 (sodium)
Chemical Formula: C17H18N5NaO6S2
Exact Mass: 475.06
Molecular Weight: 475.480
Elemental Analysis: C, 42.94; H, 3.82; N, 14.73; Na, 4.84; O, 20.19; S, 13.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 234096-34-5 (free base)   141195-77-9 (sodium)    

Synonym: Cefovecin Sodium; UK-287,074-02; UK287,074-02; UK 287,074-02;; C13142; D01681.

IUPAC/Chemical Name: Sodium (6R,7R)-7-(((2Z)-(2-aminothiazol-4-yl)(methoxyimino)acetyl)amino)-8-oxo-3-((2S)-tetrahydrofuran-2-yl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

InChi Key: QRIBXVGHDLFNNE-VQWMGBAQSA-M

InChi Code: InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10-;/t9-,11+,15+;/m0./s1

SMILES Code: [Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)[O-])[C@@H]3CCCO3)\c4csc(N)n4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 475.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nardini G, Barbarossa A, Dall'Occo A, Di Girolamo N, Cagnardi P, Magnone W, Bielli M, Roncada P, Zaghini A. Pharmacokinetics of cefovecin sodium after subcutaneous administration to Hermann's tortoises (Testudo hermanni). Am J Vet Res. 2014 Oct;75(10):918-23. doi: 10.2460/ajvr.75.10.918. PubMed PMID: 25255182.

2: Torres-Henderson C, Hesser J, Hyatt DR, Hawley J, Brewer M, Lappin MR. Pilot study to evaluate the role of Mycoplasma species in cat bite abscesses. J Feline Med Surg. 2014 Dec;16(12):997-1000. doi: 10.1177/1098612X14527475. Epub 2014 Mar 18. PubMed PMID: 24643287.

3: Silva RO, D'elia ML, de Magalhães Soares DF, Cavalcanti ÁR, Leal RC, Cavalcanti G, Pereira PL, Lobato FC. Clostridium difficile-associated diarrhea in an ocelot (Leopardus pardalis). Anaerobe. 2013 Apr;20:82-4. doi: 10.1016/j.anaerobe.2013.02.007. Epub 2013 Mar 4. PubMed PMID: 23467074.

4: Raabe BM, Lovaglio J, Grover GS, Brown SA, Boucher JF, Yuan Y, Civil JR, Gillhouse KA, Stubbs MN, Hoggatt AF, Halliday LC, Fortman JD. Pharmacokinetics of cefovecin in cynomolgus macaques (Macaca fascicularis), olive baboons (Papio anubis), and rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2011 May;50(3):389-95. PubMed PMID: 21640036; PubMed Central PMCID: PMC3103291.

5: Papp R, Popovic A, Kelly N, Tschirret-Guth R. Pharmacokinetics of Cefovecin in squirrel monkey (Saimiri sciureus), rhesus macaques (Macaca mulatta), and cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2010 Nov;49(6):805-8. PubMed PMID: 21205444; PubMed Central PMCID: PMC2994046.

6: Six R, Cleaver DM, Lindeman CJ, Cherni J, Chesebrough R, Papp G, Skogerboe TL, Weigel DJ, Boucher JF, Stegemann MR. Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds. J Am Vet Med Assoc. 2009 Jan 1;234(1):81-7. doi: 10.2460/javma.234.1.81. PubMed PMID: 19119969.