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Featured Products
PF-9184
CAT#: H522526
CAS#: 1221971-47-6
PF-9184 is a potent and selective mPGES-1 inhibitor. PF-9184 potently inhibited recombinant human (rh) mPGES-1 (IC(50)=16.5+/-3.8nM), and had no effec…
PF-9363
CAT#: H124375
CAS#: 2569009-58-9
PF-9363, also known as CTx-648, is a first-in-class potent and high selective KAT6A/KAT6B inhibitor with efficacy against KAT6A-high ER+ breast cancer…
PF-9366
CAT#: H526342
CAS#: 72882-78-1
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
PF-956980
CAT#: H563629
CAS#: 1262832-74-5
PF-956980 is a pecific JAK3 inhibitor, reversing the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia…
PF-CBP1 free base
CAT#: H406726
CAS#: 1962928-21-7 (free base)
PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates …
PF-CBP1 HCl
CAT#: H407455
CAS#: 2070014-93-4 (HCl)
PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates …
PF00835231
CAT#: H463239
CAS#: 870153-29-0
PF00835231 is a SARS CoV-1 3CLpro inhibitor for potential treatment of COVID-19.
PF04418948
CAT#: H522468
CAS#: 1078166-57-0
PF-04418948 is a novel, potent and selective prostaglandin EP2 receptor antagonist. PF-04418948 inhibited prostaglandin E(2)(PGE(2))-induced increase…
PF04471141 HCl
CAT#: H555250
CAS#: 1655498-17-1 (HCl)
PF-04471141 is a potent, selective inhibitor of the calcium-activated phosphodiesterase PDE1. (PDE1B IC50 = 35 nM).
PF05020182
CAT#: H522448
CAS#: 1354712-92-7
PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at dos…
PF05175157
CAT#: H523106
CAS#: 1301214-47-0
PF-05175157 is a potent and selective cetyl-CoA carboxylase (ACC) 1 and 2 inhibitor with IC50 values of 27 nM and 33 nM, respectively. PF-05175157 led…
PF06447475
CAT#: H406655
CAS#: 1527473-33-1
PF06447475 is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been ge…
PF06456384 HCl
CAT#: H531360
CAS#: 1834610-75-1 (HCl)
PF-06456384 is a highly potent and selective inhibitor against voltage-gated sodium channel NaV1.7 (SCN9A; IC50 = 0.01, <0.1, 75 nM against human, mou…
PF0998425
CAT#: H532464
CAS#: 1076225-27-8
PF0998425 is a bioactive chemical.
PF3450074
CAT#: H555391
CAS#: 1352879-65-2
PF-3450074, also known as PF74, is a HIV-1 inhibitor that targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers prematu…
PF4136309
CAT#: H510288
CAS#: 1341224-83-6
PF-4136309, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineopla…
PF9238
CAT#: H571262
CAS#: 1621585-17-8
PF9238 is a beta-secretase I inhibitor. Treatment with PF9238 results in the accumulation of autofluorescent granules in the retinas. PF9238 has a Cat…
PF9601N
CAT#: H531327
CAS#: 133845-63-3
PF9601N is a selective and potent monoamine oxidase B inhibitor that exhibit anti-Parkinsonian effects in several models of PD.
PFE-360
CAT#: H531326
CAS#: 1527475-61-1
PFE-360, also known asd PF-06685360, is a potent and selective inhibitor of LRRK2 kinase.
PFI-1
CAT#: H406261
CAS#: 1403764-72-6
PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of …
PFI-2 hydrochloride
CAT#: H407286
CAS#: 1627607-87-7 (HCl)
PFI-2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 …
PFI-3
CAT#: H407284
CAS#: 1819363-80-8
PFI-3 is a potent and selective SMARCA2/4 bromodomain inhibitor that binds avidly to the structurally-similar SMARCA4 bromodomain and PB1(bromodomain …
PFI-4
CAT#: H407154
CAS#: 900305-37-5
PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 = 80 nM. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by IT…
PFI-653
CAT#: H555648
CAS#: 2173134-00-2
PFI-653, also known as Vanin-1-IN-1, is an inhibitor of vanin-1 (VNN1) enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) …
PFK-015
CAT#: H406616
CAS#: 4382-63-2
PFK-015 is a potent inhibitor of PFKFB3. The preliminary results in a U87GM xenograft model have shown that PFK-015 has comparable activity to Temozol…
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