WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584202
CAS#: 191868-14-1 (TFA)
Description: BIBO-3304 is a selective Y1 receptor antagonist. Y1 receptor proteins from neuropeptide Y have a roll in appetite stimulation.
Hodoodo Cat#: H584202
Name: BIBO-3304 TFA
CAS#: 191868-14-1 (TFA)
Chemical Formula: C33H37F6N7O7
Exact Mass: 0.00
Molecular Weight: 757.690
Elemental Analysis: C, 52.31; H, 4.92; F, 15.04; N, 12.94; O, 14.78
Related CAS #: 191868-13-0 (free base) 191868-14-1 (TFA)
Synonym: BIBO-3304; BIBO 3304; BIBO3304; BIBO-3304 TFA
IUPAC/Chemical Name: (R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide bis(2,2,2-trifluoroacetate)
InChi Key: XWZMETGYCRXJJH-PPLJNSMQSA-N
InChi Code: InChI=1S/C29H35N7O3.2C2HF3O2/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23;2*3-2(4,5)1(6)7/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39);2*(H,6,7)/t24-;;/m1../s1
SMILES Code: O=C(N[C@@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | BIBO3304 TFA is a neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor with IC50s of 0.38 and 0.72 nM, respectively. |
| In vitro activity: | The selective Y1 receptor antagonist, BIBO 3304, concentration-dependently inhibited vasoconstrictive and proliferative effects of neuropeptide Y (NPY) in vitro. Reference: Br J Pharmacol. 2014 Aug;171(16):3895-907. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128051/ |
| In vivo activity: | Treatment with BIBO-3304, a NPY receptor antagonist, significantly suppressed development of house dust mite (HDM) induced airway hyperresponsiveness (AHR) and inflammation in wild-type mice.4 Reference: Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L407-L417. https://journals.physiology.org/doi/full/10.1152/ajplung.00386.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 87.9 | 116.00 | |
| Ethanol | 15.2 | 19.99 |
The following data is based on the product molecular weight 757.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Crnkovic S, Egemnazarov B, Jain P, Seay U, Gattinger N, Marsh LM, Bálint Z, Kovacs G, Ghanim B, Klepetko W, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G. NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension. Br J Pharmacol. 2014 Aug;171(16):3895-907. doi: 10.1111/bph.12751. PMID: 24779394; PMCID: PMC4128051. 2. Oda N, Miyahara N, Taniguchi A, Morichika D, Senoo S, Fujii U, Itano J, Gion Y, Kiura K, Kanehiro A, Maeda Y. Requirement for neuropeptide Y in the development of type 2 responses and allergen-induced airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L407-L417. doi: 10.1152/ajplung.00386.2018. Epub 2019 Jan 3. PMID: 30604629. |
| In vitro protocol: | 1. Crnkovic S, Egemnazarov B, Jain P, Seay U, Gattinger N, Marsh LM, Bálint Z, Kovacs G, Ghanim B, Klepetko W, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G. NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension. Br J Pharmacol. 2014 Aug;171(16):3895-907. doi: 10.1111/bph.12751. PMID: 24779394; PMCID: PMC4128051. |
| In vivo protocol: | 1. Oda N, Miyahara N, Taniguchi A, Morichika D, Senoo S, Fujii U, Itano J, Gion Y, Kiura K, Kanehiro A, Maeda Y. Requirement for neuropeptide Y in the development of type 2 responses and allergen-induced airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L407-L417. doi: 10.1152/ajplung.00386.2018. Epub 2019 Jan 3. PMID: 30604629. |
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