WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591927
CAS#: 3545-67-3 (HCl)
Description: Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated (to CQ2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup
Hodoodo Cat#: H591927
Name: Chloroquine HCl
CAS#: 3545-67-3 (HCl)
Chemical Formula: C18H28Cl3N3
Exact Mass: 0.00
Molecular Weight: 392.793
Elemental Analysis: C, 55.04; H, 7.19; Cl, 27.08; N, 10.70
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Related CAS #: 54-05-7 (free base) 132-73-0 (sulfate) 1446-17-9 (phosphate) 3545-67-3 (HCl) 50-63-5 (diphosphate) 151-69-9 (acetate)
Synonym: NSC 14050; NSC-14050; NSC14050; Chloroquine hydrochloride; Aralen hydrochloride; Aralen HCl;
IUPAC/Chemical Name: N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
InChi Key: PCFGECQRSMVKCC-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H26ClN3.2ClH/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;;/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*1H
SMILES Code: CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)CC.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info: Chloroquine binds to heme (or FP) to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Parasites that do not form hemozoin are therefore resistant to chloroquine.
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The following data is based on the product molecular weight 392.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
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