WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412961
CAS#: 132-73-0 (sulfate)
Description: Chloroquine sulfate is the prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
Hodoodo Cat#: H412961
Name: Chloroquine sulfate
CAS#: 132-73-0 (sulfate)
Chemical Formula: C18H28ClN3O4S
Exact Mass: 417.15
Molecular Weight: 417.945
Elemental Analysis: C, 51.73; H, 6.75; Cl, 8.48; N, 10.05; O, 15.31; S, 7.67
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 54-05-7 (free base) 132-73-0 (sulfate) 1446-17-9 (phosphate) 3545-67-3 (HCl) 50-63-5 (diphosphate) 151-69-9 (acetate)
Synonym: Chloroquine sulfate; NSC292296; NSC-292296; NSC 292296
IUPAC/Chemical Name: 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, sulfate (1:1) (9CI)
InChi Key: OJPWHUOVKVKBQB-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H26ClN3.H2O4S/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H2,1,2,3,4)
SMILES Code: CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)CC.O=S(O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 417.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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2: McChesney EW. Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate. Am J Med. 1983 Jul 18;75(1A):11-8. doi: 10.1016/0002-9343(83)91265-2. PMID: 6408923.
3: Fantini J, Di Scala C, Chahinian H, Yahi N. Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection. Int J Antimicrob Agents. 2020 May;55(5):105960. doi: 10.1016/j.ijantimicag.2020.105960. Epub 2020 Apr 3. PMID: 32251731; PMCID: PMC7128678.
4: Touret F, de Lamballerie X. Of chloroquine and COVID-19. Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5. PMID: 32147496; PMCID: PMC7132364.
5: Lentini G, Cavalluzzi MM, Habtemariam S. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. Molecules. 2020 Apr 16;25(8):1834. doi: 10.3390/molecules25081834. PMID: 32316270; PMCID: PMC7221598.
6: Ochsendorf FR, Runne U. Chloroquin und Hydroxychloroquin: Nebenwirkungsprofil wichtiger Therapeutika [Chloroquine and hydroxychloroquine: side effect profile of important therapeutic drugs]. Hautarzt. 1991 Mar;42(3):140-6. German. PMID: 2055762.
7: Mohr K. Chloroquin [Chloroquine]. Dtsch Med Wochenschr. 1994 Feb 25;119(8):273-4. German. doi: 10.1055/s-0029-1235021. PMID: 8112211.
8: Martinez GP, Zabaleta ME, Di Giulio C, Charris JE, Mijares MR. The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. Curr Pharm Des. 2020;26(35):4467-4485. doi: 10.2174/1381612826666200707132920. PMID: 32634079.
9: Gevers S, Kwa MSG, Wijnans E, van Nieuwkoop C. Safety considerations for chloroquine and hydroxychloroquine in the treatment of COVID-19. Clin Microbiol Infect. 2020 Sep;26(9):1276-1277. doi: 10.1016/j.cmi.2020.05.006. Epub 2020 May 16. PMID: 32422406; PMCID: PMC7228887.
10: Gao Q. [Pharmacological characteristics of chloroquine and suggestions for its use in treatment of coronavirus disease 2019 (COVID-19)]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Apr 22;32(2):119-122. Chinese. doi: 10.16250/j.32.1374.2020092. PMID: 32458599.