WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574270
CAS#: 1375073-93-0 (free base)
Description: Exaluren, also known as NB-124 and ELX 02 is a a synthetic aminoglycoside and a translational read-through inducer. ELX-02 suppresses translation termination at PTCs (i.e., readthrough) by promoting the insertion of an amino acid at the PTC and restoring expression of full-length CFTR protein. After treatment with ELX-02 and CFTR correctors, CFTR function rescued from the G550X allele in FRTs reached 20–40% of the wild-type level. Exaluren is being developed as a therapy for genetic diseases caused by nonsense mutations.
Hodoodo Cat#: H574270
Name: Exaluren free base
CAS#: 1375073-93-0 (free base)
Chemical Formula: C19H38N4O10
Exact Mass: 482.26
Molecular Weight: 482.530
Elemental Analysis: C, 47.29; H, 7.94; N, 11.61; O, 33.16
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Related CAS #: 1375073-93-0 (free base) 1375073-96-3 (sulfate),
Synonym: Exaluren; NB-124; NB 124; NB124; NB-124; ELX 02; ELX-02; ELX 02;
IUPAC/Chemical Name: (2R,3S,4R,5R,6S)-5-amino-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2-(((2S,3R,4S,5R)-5-((S)-1-aminoethyl)-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-3-hydroxycyclohexyl)oxy)-2-((R)-1-hydroxyethyl)tetrahydro-2H-pyran-3,4-diol
InChi Key: KJBRSTPUILEBDR-DBMIJKFDSA-N
InChi Code: InChI=1S/C19H38N4O10/c1-4(20)14-12(28)13(29)19(30-14)33-17-9(25)6(21)3-7(22)16(17)32-18-8(23)10(26)11(27)15(31-18)5(2)24/h4-19,24-29H,3,20-23H2,1-2H3/t4-,5+,6+,7-,8+,9-,10+,11-,12-,13+,14+,15+,16+,17+,18+,19-/m0/s1
SMILES Code: N[C@@H]1[C@@H](O[C@H]2O[C@]([H])([C@H](O)C)[C@@H](O)[C@H](O)[C@H]2N)[C@H](O[C@@H]3O[C@]([H])([C@@H](N)C)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](N)C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 482.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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