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16
Angiogenesis
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12
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19
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Adenosine Receptor
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4
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10
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20
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5
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17
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2
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MEK Products
or product name starting with:
A
B
C
D
E
F
G
H
I
J
K
L
M
N
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Z
H404210
U0126
featured
U0126 is a potent and selective non-competitive inhibitor of MAP kinase. Inhibits MEK-1 and MEK-2 (I…
H406198
RO5068760
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)…
H406298
RO4927350
RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selective…
H406212
PF-04880594
featured
PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epit…
H406475
PD166866
featured
PD166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, a…
H406195
PD318088
featured
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a re…
H406196
PD184161
featured
PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a …
H406274
LCH-7749944
LCH-7749944, also known as GNF-Pf-2356, is a novel and potent PAK4 inhibitor, which effectively supp…
H401483
GW5074
featured
GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-asso…
H406200
G-573
featured
G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK…
H406199
CInQ-03
CInQ-03 is a novel and specific MEK inhibitor both in vitro and in vivo.
H204730
XL-281
XL281, also known as BMS-908662 , is an orally active, small molecule Raf kinase inhibitor with pote…
H206014
XK469
XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiprolifer…
H206012
WX-554
WX-554 is an orally available small molecule mitogen-activated protein kinase kinase (MAP2K, MAPK/ER…
H205638
TAK-733
featured
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential …
H205736
SNX-2112
featured
SNX-2112, also known as PF 04928473, is an Hsp90 inhibitor which is currently undergoing multiple p…
H200300
Selumetinib (AZD6244)
featured
Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineop…
H205788
RO5126766
featured
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitog…
H202462
RO4987655
featured
RO4987655, also known as CH4987655, is an orally active small molecule, targeting mitogen-activated…
H205609
RG7167
RG7167 is a potent, orally bioavailable, highly selective MEK inhibitor. It potently inhibits the MA…
H202431
Refametinib
featured
Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor w…
H202432
RDEA-436
RDEA-436 is a second-generation mitogen-activated ERK kinase inhibitor for the treatment of cancer. …
H202172
Mirdametinib
featured
Mirdametinib, also known as PD-0325901, is a potent bioavailable and selective MEK inhibitor, which…
H205531
Binimetinib (MEK-162)
featured
Binimetinib, also known as MEK162 (ARRY-162), is an oral, highly selective MEK inhibitor. In preclin…
H206161
LY3009120
featured
LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticance…
H205852
Encorafenib
featured
Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antin…
H203185
Cobimetinib
featured
Cobimetinib, also known as GDC-0973 and XL-518, RG 7420, is an orally bioavailable small-molecule in…
H205772
GDC-0623
featured
GDC-0623, also known as G-868, is an orally active, selective MEK inhibitor with potential antineopl…
H201071
E6201
E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinas…
H205612
RG7304
RG7304, also known as R7304 or CK-127, is a MEK inhibitor currently in clinical trials.
H200771
CI-1040
featured
CI-1040, also known as PD184352, is a MEK inhibitor, which demonstrated in vivo activity in preclini…
H200770
RAF-265 (CHIR-265)
featured
RAF-265, also known as CHIR-265, is an orally bioavailable small molecule with potential antineoplas…
H205903
RXDX-105 (CEP-32496)
featured
RXDX-105, also known as Agerafenib, CEP-32496 and AC013773, is an orally available v-raf murine sarc…
H200313
AZD-8330
featured
AZD8330, also known as ARRY704 and ARRY424704, is an orally active, selective MEK inhibitor with po…
H205859
AS703988
AS703988, also known as MSC201510B, is an orally bioavailable small-molecule inhibitor of mitogen-ac…
H200297
Pimasertib
featured
Pimasertib, also known as AS703026, SAR245509, MSC1936369B, is an orally bioavailable small-molecule…
H200121
AG-490
new
featured
Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal tr…
H401680
PD98059
featured
PD98059 also known as PD-98059, is a potent and selective inhibitor of MAP kinase kinase (also know…
H406197
SL327
featured
SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned…
H406645
CCT196969
featured
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT196969 blocked g…
H406644
CCT241161
featured
CCT241161 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT241161 blocked g…
H406623
SMK-17
SMK-17 is a potent MEK1/2 inhibitor with high aqueous solubility. SMK-17 inhibited MEK1 kinase activ…
H406596
G-479
G-479 is an potent MEK inhibitor. Structurally, G-479 is an analogue of GDC-0623 (or so-call Me-Too …
H201458
Trametinib
featured
Trametinib, also known as GSK1120212, is a n orally bioavailable inhibitor of mitogen-activated prot…
H205737
Debio-0932
featured
Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong a…
H406531
Kobe0065
featured
Kobe0065 is a small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effe…
H406580
Kobe-2602
featured
Kobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibito…