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16
Angiogenesis
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19
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10
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20
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17
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2
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Raf Products
or product name starting with:
A
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H404210
U0126
featured
U0126 is a potent and selective non-competitive inhibitor of MAP kinase. Inhibits MEK-1 and MEK-2 (I…
H406109
SB-590885
featured
SB-590885 is a novel triarylimidazole that selectively inhibits Raf kinases with more potency toward…
H406212
PF-04880594
featured
PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epit…
H401562
NVP-BEP800
new
featured
NVP-BEP800, also known as BEP-800, is a novel, fully synthetic, orally bioavailable inhibitor that …
H401483
GW5074
featured
GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-asso…
H401470
GDC-0879
featured
GDC-0879 is a highly selective, potent, and orally bioavailable RAF small-molecule inhibitor. In GDC…
H406299
FTI-276
FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimeti…
H204730
XL-281
XL281, also known as BMS-908662 , is an orally active, small molecule Raf kinase inhibitor with pote…
H206012
WX-554
WX-554 is an orally available small molecule mitogen-activated protein kinase kinase (MAP2K, MAPK/ER…
H205638
TAK-733
featured
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential …
H205736
SNX-2112
featured
SNX-2112, also known as PF 04928473, is an Hsp90 inhibitor which is currently undergoing multiple p…
H200300
Selumetinib (AZD6244)
featured
Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineop…
H205788
RO5126766
featured
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitog…
H202462
RO4987655
featured
RO4987655, also known as CH4987655, is an orally active small molecule, targeting mitogen-activated…
H206168
PLX8394 (removed)
PLX8394 is an orally bioavailable inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein …
H202172
Mirdametinib
featured
Mirdametinib, also known as PD-0325901, is a potent bioavailable and selective MEK inhibitor, which…
H205777
Tovorafenib
featured
Tovorafenib. also known as TAK-580, MLN2480, BIIB024, and AMG 2112819, DAY101, is an oral, selectiv…
H206161
LY3009120
featured
LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticance…
H205852
Encorafenib
featured
Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antin…
H203185
Cobimetinib
featured
Cobimetinib, also known as GDC-0973 and XL-518, RG 7420, is an orally bioavailable small-molecule in…
H205772
GDC-0623
featured
GDC-0623, also known as G-868, is an orally active, selective MEK inhibitor with potential antineopl…
H201071
E6201
E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinas…
H206144
Donafenib
Donafenib, also known as CM-4307, is an oral multikinase inhibitor that targets Raf kinase and recep…
H206008
Diazepinomicin
Diazepinomicin, also known as TLN-4601 and BU 4664L, is a small-molecule inhibitor of the RAS/RAF/MA…
H200770
RAF-265 (CHIR-265)
featured
RAF-265, also known as CHIR-265, is an orally bioavailable small molecule with potential antineoplas…
H205903
RXDX-105 (CEP-32496)
featured
RXDX-105, also known as Agerafenib, CEP-32496 and AC013773, is an orally available v-raf murine sarc…
H200505
BIIB021
new
featured
BIIB021, also known as CNF2024, is an orally active, purine-scaffold, small-molecule inhibitor of he…
H200313
AZD-8330
featured
AZD8330, also known as ARRY704 and ARRY424704, is an orally active, selective MEK inhibitor with po…
H205859
AS703988
AS703988, also known as MSC201510B, is an orally bioavailable small-molecule inhibitor of mitogen-ac…
H200297
Pimasertib
featured
Pimasertib, also known as AS703026, SAR245509, MSC1936369B, is an orally bioavailable small-molecule…
H204440
ARQ-736
ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer ce…
H406300
FTI-277 HCl
featured
FTI-277 is a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently…
H406667
L-779450
featured
L-779450 is a potent, selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM). L-779450 su…
H406645
CCT196969
featured
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT196969 blocked g…
H406644
CCT241161
featured
CCT241161 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT241161 blocked g…
H406606
VER-49009
featured
VER-49009 is a potent HSP90 inhibitor. VER-49009 inhibits Hsp90 with an IC50 value of 47 nM. VER-490…
H201458
Trametinib
featured
Trametinib, also known as GSK1120212, is a n orally bioavailable inhibitor of mitogen-activated prot…
H406295
TAK-632
featured
TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BR…
H202436
Regorafenib
featured
Regorafenib, also known as BAY 73-4506; binds to and inhibits vascular endothelial growth factor rec…
H202272
PLX4720
featured
PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a cl…
H205737
Debio-0932
featured
Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong a…
H406110
AZ-628
featured
AZ-628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and…
H405650
ZM336372
featured
ZM336372 is a Raf-1 activating agent, has been shown to cause growth inhibition and suppression of h…
H406531
Kobe0065
featured
Kobe0065 is a small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effe…
H406580
Kobe-2602
featured
Kobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibito…
H205479
Dabrafenib
featured
Dabrafenib, also known as GSK2118436 , is an orally bioavailable inhibitor of B-raf (BRAF) protein w…