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H406229
XL388
featured
XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibit…
H406366
WYE-125132
featured
WYE-125132, also known as WYE-132, is a highly potent, ATP-competitive, and specific mTOR kinase inh…
H406367
WYE-687
new
featured
WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
H405150
WYE-354
featured
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through …
H406365
WAY-600
new
featured
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
H404210
U0126
featured
U0126 is a potent and selective non-competitive inhibitor of MAP kinase. Inhibits MEK-1 and MEK-2 (I…
H406324
PKI-402
featured
PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylino…
H406248
PF-05139962
PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular po…
H406304
MG-132
featured
MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It re…
H406250
GNE-555
GNE-555 is a novel, orally bioavailable, potent and selective mTOR inhibitor with potential anticanc…
H401220
Chrysophanic acid
featured
Chrysophanic acid (Chrysophanol ) is a a natural anthraquinone, has anticancer activity in EGFR-over…
H406439
AZ7328
AZ7328 is a potent and selective AKT inhibitor. AZ7328 inhibited proliferation and AKT substrate pho…
H203187
Voxtalisib
featured
Voxtalisib, also known as XL-765 and SAR245409, is a PI3K/mTOR dual kinase inhibitor XL765 is an ora…
H206109
VS-5584
featured
VS-5584, also known as SB2343, is a potent and selective inhibitor of both phosphatidylinositol 3 ki…
H202601
SF1126
SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF…
H200860
Ridaforolimus
featured
Ridaforolimus, also known as AP23573, is an investigational small-molecule inhibitor of mTOR, a prot…
H202360
Sonolisib (PX-866)
featured
Sonolisib, also known as PX-866, is a small-molecule wortmannin analogue inhibitor of the alpha, gam…
H205745
PWT33597 mesylate
PWT33597, also known as VDC-597, is an orally bioavailable dual inhibitor of phosphatidylinositide …
H206146
Bimiralisib free base
new
featured
Bimiralisib, also known as PQR309, is an orally bioavailable pan inhibitor of phosphoinositide-3-ki…
H202324
Torkinib (PP242)
featured
Torkinib, also known as PP242 is a selective mTOR inhibitor with IC50 of 8 nM. PP242 suppresses blad…
H205989
PKI-179
featured
PKI-179 is a second generation, small-molecule mimetic of ATP that targets the mammalian target of r…
H202235
PI-103
new
featured
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K…
H202226
PF-04691502
new
featured
PF-04691502 is a PI3K/mTOR kinase inhibitor , is also an agent targeting the phosphatidylinositol 3 …
H202190
Pelitinib
featured
Pelitinib, also known as EKB569 and WAY-172569, is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhi…
H202070
Oleandrin
featured
Oleandrin, also known as PBI-05204 , is a lipid soluble cardiac glycoside with potential antineoplas…
H205743
MLN-1117
featured
Serabelisib (also known as MLN1117, INK1117, and TAK-117) is an orally bioavailable inhibitor of the…
H205495
Sapanisertib (MLN0128)
featured
Sapanisertib, also known as TAK-228, MLN0128 and INK128, is a TORC1/2 inhibitor, is an orally bioava…
H201920
MKC-1
new
featured
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with poten…
H205856
ME-344
ME-344 is an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalia…
H206214
Samotolisib
featured
Samotolisib, also known as LY3023414, is a small molecule that has been shown in vitro to be a selec…
H205776
KU-0063794
featured
KU-0063794 is a potent and selective mTOT inhibitor, which inhibits both mTORC1 and mTORC2 with an I…
H203060
KRX-0601
featured
KRX-0601, also known as UCN-01, is a synthetic derivative of staurosporine with antineoplastic activ…
H206085
GRD081
GRD081 is a dual PI3K/mTOR inhibitor. The no-observed-adverse-effect level (NOAEL) of GRD081 was 1mg…
H205836
DS-7423
DS-7423 is an orally bioavailable inhibitor of phosphatidylinositol 3 kinase (PI3K) and mammalian ta…
H205961
DS-3078a
DS-3078a is an orally bioavailable inhibitor of raptor-mTOR protein complex (TORC1) and rictor-mTOR …
H205924
Fimepinostat
featured
CUDC-907, also known as fimepinostat, is an orally bioavailable inhibitor of both phosphoinositide 3…
H205747
CH5132799
featured
CH5132799, also known as PA-799, is a novel class I PI3K inhibitor, which exhibited a strong inhibi…
H205829
CC-115
new
featured
CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamyci…
H200491
Dactolisib
featured
Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inh…
H206151
BAY1125976 HCl
BAY1125976 is an orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein k…
H205923
BAY1082439
featured
BAY1082439 is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha…
H200312
AZD-8055
featured
AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic a…
H202870
Temsirolimus
featured
Temsirolimus is an ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian targe…
H406155
IC-87114
featured
IC-87114 is a potent and ATP-competitive PI3K p110δ isoform-selective inhibitor (IC50 = 60 nM). It I…
H205669
Capivasertib
featured
AZD5363, also known as Capivasertib, is an orally available inhibitor of the serine/threonine protei…
H406654
MHY1485
featured
MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autop…
H406599
GNE-493
featured
GNE-493 is potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhib…
H406260
AZD8186
new
featured
AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential ant…
H406432
PF-4708671
featured
PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 is…
H202133
Palomid-529
featured
Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the…
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